Denser brain capillary network with preserved pericytes in Alzheimer's disease.
Denser brain capillary network with preserved pericytes in Alzheimer's disease.
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DOI：
10.1111/bpa.12897
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Priller J
中科院分区：
文献类型：
--
作者：
Fernandez-Klett F;Brandt L;Fernández-Zapata C;Abuelnor B;Middeldorp J;Sluijs JA;Curtis M;Faull R;Harris LW;Bahn S;Hol EM;Priller J
周细胞是围绕中枢神经系统（CNS）的毛细血管的血管壁细胞。它们对大脑发育至关重要，并通过调节血脑屏障功能和脑血流来促进CNS稳态。已经提出，周细胞在阿尔茨海默病（AD）中丢失，这暗示了这种细胞类型在疾病病理学中的作用。在这里，我们采用了最先进的体视学形态测量技术以及组织清除和双光子成像来评估AD（n = 16和13）和非痴呆对照（n = 16和4）两个独立队列中周细胞的分布。体视学定量显示AD脑额叶皮质中毛细血管密度增加，周细胞群正常，这是一个早期淀粉样蛋白β沉积的区域。对清除的额叶皮质组织的双光子分析证实了AD病例中周细胞的保存。这些结果表明，周细胞死亡不是AD病理学的一般标志。
Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer's disease (AD), implicating this cell type in disease pathology. Here, we have employed state‐of‐the‐art stereological morphometry techniques as well as tissue clearing and two‐photon imaging to assess the distribution of pericytes in two independent cohorts of AD (n = 16 and 13) and non‐demented controls (n = 16 and 4). Stereological quantification revealed increased capillary density with a normal pericyte population in the frontal cortex of AD brains, a region with early amyloid β deposition. Two‐photon analysis of cleared frontal cortex tissue confirmed the preservation of pericytes in AD cases. These results suggest that pericyte demise is not a general hallmark of AD pathology.
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