Targeting drug tolerance in mycobacteria: a perspective from mycobacterial biofilms.
Targeting drug tolerance in mycobacteria: a perspective from mycobacterial biofilms.
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DOI：
10.1586/eri.12.88
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发表时间：
2012-09
影响因子：
5.7
通讯作者：
Ojha AK
中科院分区：
文献类型：
--
作者：
Islam MS;Richards JP;Ojha AK
Multidrug chemotherapy for 6–9-months is one of the primary treatments in effective control of tuberculosis, although the mechanisms underlying the persistence of its etiological agent, Mycobacterium tuberculosis, against antibiotics remain unclear. Ever-mounting evidence indicates that the survival of many environmental and pathogenic microbial species against antibiotics is influenced by their ability to grow as surface-associated multicellular communities called biofilms. In recent years, several mycobacterial species, including M. tuberculosis, have been found to form drug-tolerant biofilms in vitro through genetically controlled mechanisms. In this review, the authors discuss the relevance of the in vitro mycobacterial biofilms in understanding the antibiotic recalcitrance of tuberculosis infections.
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