Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds.
Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds.
复制标题
硅烷改性透辉石可改善复合支架的界面附着力和生物活性
DOI：
10.3390/molecules22040511
复制
发表时间：
2017-03-23
期刊：
影响因子：
--
通讯作者：
Peng S
中科院分区：
文献类型：
--
作者：
Shuai C;Shuai C;Feng P;Yang Y;Xu Y;Qin T;Yang S;Gao C;Peng S
将透辉石（DIOP）引入通过选择性激光烧结制造的聚醚醚酮/聚乙醇酸（PEEK/PGA）支架中以提高生物活性。然后使用硅烷偶联剂 3-缩水甘油氧基丙基三甲氧基硅烷 (KH570) 对 DIOP 表面进行改性，以增强界面粘附力。结果表明，支架的拉伸性能和热稳定性显着增强。这可以解释为，一方面，KH570的亲水基团与DIOP表面的羟基形成有机共价键。另一方面，其疏水基团与生物聚合物基质之间存在较高的相容性。因此，改善的界面相互作用导致基体中 DIOP 分散的均匀状态。更重要的是，体外生物活性研究表明，含有KH570修饰的DIOP（KDIOP）的支架表现出形成磷灰石层的能力。此外，细胞培养实验表明，与不含KDIOP的支架相比，它们具有良好的生物相容性。这表明KDIOP支架在组织工程中具有潜在的应用前景。
Diopside (DIOP) was introduced into polyetheretherketone/polyglycolicacid (PEEK/PGA) scaffolds fabricated via selective laser sintering to improve bioactivity. The DIOP surface was then modified using a silane coupling agent, 3-glycidoxypropyltrimethoxysilane (KH570), to reinforce interfacial adhesion. The results showed that the tensile properties and thermal stability of the scaffolds were significantly enhanced. It could be explained that, on the one hand, the hydrophilic group of KH570 formed an organic covalent bond with the hydroxy group on DIOP surface. On the other hand, there existed relatively high compatibility between its hydrophobic group and the biopolymer matrix. Thus, the ameliorated interface interaction led to a homogeneous state of DIOP dispersion in the matrix. More importantly, an in vitro bioactivity study demonstrated that the scaffolds with KH570-modified DIOP (KDIOP) exhibited the capability of forming a layer of apatite. In addition, cell culture experiments revealed that they had good biocompatibility compared to the scaffolds without KDIOP. It indicated that the scaffolds with KDIOP possess potential application in tissue engineering.
登录
查看更多内容
影响因子：
8
作者：
Deng Y;Liu X;Xu A;Wang L;Luo Z;Zheng Y;Deng F;Wei J;Tang Z;Wei S
通讯作者：
Wei S
DOI：
10.3390/molecules201219804
发表时间：
2015-12-04
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Dragojevic S;Ryu JS;Raucher D
通讯作者：
Raucher D
影响因子：
3.4
作者：
Fiocco L;Elsayed H;Ferroni L;Gardin C;Zavan B;Bernardo E
通讯作者：
Bernardo E
介孔透辉石/聚丙交酯复合材料介孔/大孔支架的生物相容性、降解性、生物活性和成骨作用
影响因子：
3.9
作者：
Liu, Zhulin;Ji, Jiajin;Wei, Jie
通讯作者：
Wei, Jie
影响因子：
8.4
作者：
Chauhan, S. R.;Thakur, Sunil
通讯作者：
Thakur, Sunil