Oxidative stress and immunosenescence: therapeutic effects of melatonin.
Oxidative stress and immunosenescence: therapeutic effects of melatonin.
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DOI：
10.1155/2012/670294
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发表时间：
2012
影响因子：
--
通讯作者：
Rodríguez AB
中科院分区：
文献类型：
--
作者：
Espino J;Pariente JA;Rodríguez AB
与年龄相关的免疫系统恶化，也就是免疫衰老，会增加老年人感染传染病、自身免疫和癌症的可能性。本文对免疫系统中与衰老相关的主要变化进行了综述。一般而言，免疫衰老的特征是胸腺来源的外周幼稚T细胞水平降低和骨髓中未成熟B细胞的丧失。巨噬细胞和粒细胞则随增龄而功能衰退，吞噬功能减弱，超氧化物生成障碍。吲哚褪黑素主要分泌在松果体中，尽管在许多其他组织中也发现了它。由于循环中的褪黑素随着年龄的增长而减少，与年龄相关的免疫系统的下降相吻合，褪黑素的免疫调节作用近年来引起了人们的极大兴趣。在这里，我们强调了褪黑素表现出的抗氧化和免疫增强作用，从而为这种吲哚胺作为一种“替代疗法”的潜在应用提供了证据，以限制或逆转免疫衰老过程中发生的一些变化的影响。
Age-associated deterioration in the immune system, which is referred to as immunosenescence, contributes to an increased susceptibility to infectious diseases, autoimmunity, and cancer in the elderly. A summary of major changes associated with aging in immune system is described in this paper. In general, immunosenescence is characterized by reduced levels of peripheral naïve T cells derived from thymus and the loss of immature B lineage cells in the bone marrow. As for macrophages and granulocytes, they show functional decline with advancing age as evidenced by their diminished phagocytic activity and impairment of superoxide generation. The indole melatonin is mainly secreted in the pineal gland although it has been also detected in many other tissues. As circulating melatonin decreases with age coinciding with the age-related decline of the immune system, much interest has been focused on melatonin's immunomodulatory effect in recent years. Here, we underlie the antioxidant and immunoenhancing actions displayed by melatonin, thereby providing evidence for the potential application of this indoleamine as a “replacement therapy” to limit or reverse some of the effects of the changes that occur during immunosenescence.
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影响因子：
3.5
作者：
Arendt, J;Skene, DJ;Deacon, S
通讯作者：
Deacon, S
DOI：
10.2478/v10136-011-0009-0
发表时间：
2012-01-01
期刊：
JOURNAL OF APPLIED BIOMEDICINE
影响因子：
--
作者：
Delgado, Jonathan;del Pilar Terron, Maria;Beatriz Rodriguez, Ana
通讯作者：
Beatriz Rodriguez, Ana
影响因子：
3.9
作者：
Albright, JW;Bream, JH;Ortaldo, JR
通讯作者：
Ortaldo, JR
影响因子：
3.2
作者：
Bassi, AM;Ledda, S;Cottalasso, D
通讯作者：
Cottalasso, D
影响因子：
3.3
作者：
Garcia-Mauriño, S;Gonzalez-Haba, MG;Guerrero, JM
通讯作者：
Guerrero, JM