Quantitative Susceptibility Mapping in Parkinson's Disease.
Quantitative Susceptibility Mapping in Parkinson's Disease.
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DOI：
10.1371/journal.pone.0162460
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Schwingenschuh P
中科院分区：
文献类型：
--
作者：
Langkammer C;Pirpamer L;Seiler S;Deistung A;Schweser F;Franthal S;Homayoon N;Katschnig-Winter P;Koegl-Wallner M;Pendl T;Stoegerer EM;Wenzel K;Fazekas F;Ropele S;Reichenbach JR;Schmidt R;Schwingenschuh P
定量磁敏感性成像（QSM）和R2* 弛豫率成像已证实原发性帕金森病（PD）患者黑质铁沉积增加。然而，在其他皮质下深部灰质核团的研究结果是匡威的，QSM和R2* 的形态学变化的敏感性和它们的关系，疾病严重程度的临床措施，迄今为止，只有稀疏的调查。当地伦理委员会批准了本研究，所有受试者均提供了书面知情同意书。66例原发性帕金森病患者和58例对照者在3 T下接受定量MRI。磁化率和R2* 地图重建从一个破坏的多回波三维梯度回波序列。在皮质下深灰质核中测量平均磁化率和R2* 率，并在PD患者和对照组之间进行比较，以及与临床变量相关。与对照受试者相比，PD患者的黑质R2* 值增加。在PD患者的黑质、红核、丘脑和苍白球中，QSM也显示出较高的敏感性。这些结构的几个磁化率与左旋多巴等效日剂量（LEDD）和运动和非运动疾病严重程度的临床标志物（总MDS-MRS，MDS-MRS-I和II）相关。Hoehn & Yahr量表评估的疾病严重程度与黑质的磁化率相关。通过QSM扩展了黑质中R2* 率较高的既定发现，显示出对黑质纹状体多巴胺能通路中PD相关组织变化的上级敏感性。QSM还反映了左旋多巴剂量和疾病严重程度。这些结果表明，更广泛的病理参与和QSM作为一种新的手段，其调查，比目前的MRI技术更敏感。
Quantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson’s disease (PD). However, the findings in other subcortical deep gray matter nuclei are converse and the sensitivity of QSM and R2* for morphological changes and their relation to clinical measures of disease severity has so far been investigated only sparsely. The local ethics committee approved this study and all subjects gave written informed consent. 66 patients with idiopathic Parkinson’s disease and 58 control subjects underwent quantitative MRI at 3T. Susceptibility and R2* maps were reconstructed from a spoiled multi-echo 3D gradient echo sequence. Mean susceptibilities and R2* rates were measured in subcortical deep gray matter nuclei and compared between patients with PD and controls as well as related to clinical variables. Compared to control subjects, patients with PD had increased R2* values in the substantia nigra. QSM also showed higher susceptibilities in patients with PD in substantia nigra, in the nucleus ruber, thalamus, and globus pallidus. Magnetic susceptibility of several of these structures was correlated with the levodopa-equivalent daily dose (LEDD) and clinical markers of motor and non-motor disease severity (total MDS-UPDRS, MDS-UPDRS-I and II). Disease severity as assessed by the Hoehn & Yahr scale was correlated with magnetic susceptibility in the substantia nigra. The established finding of higher R2* rates in the substantia nigra was extended by QSM showing superior sensitivity for PD-related tissue changes in nigrostriatal dopaminergic pathways. QSM additionally reflected the levodopa-dosage and disease severity. These results suggest a more widespread pathologic involvement and QSM as a novel means for its investigation, more sensitive than current MRI techniques.
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通过定量磁敏感图测量帕金森病中铁的区域渐进积累
影响因子：
2.9
作者：
Guan X;Xuan M;Gu Q;Huang P;Liu C;Wang N;Xu X;Luo W;Zhang M
通讯作者：
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DOI：
10.1002/mds.26417
发表时间：
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期刊：
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影响因子：
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影响因子：
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