Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study.
Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study.
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DOI：
10.3389/fnagi.2021.744872
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发表时间：
2021
影响因子：
4.8
通讯作者：
AIBL Investigators
中科院分区：
文献类型：
--
作者：
Gardener SL;Rainey-Smith SR;Villemagne VL;Fripp J;Doré V;Bourgeat P;Taddei K;Fowler C;Masters CL;Maruff P;Rowe CC;Ames D;Martins RN;AIBL Investigators
背景：在世界范围内，咖啡是最受欢迎的饮料之一。多项研究表明咖啡具有保护作用，包括降低患阿尔茨海默病 (AD) 的风险。然而，来自老年人群体的纵向数据有限，报告咖啡摄入量与认知能力下降在不同领域的关联，并调查了支撑任何此类关联的神经病理学机制。方法：本研究的目的是调查自我报告的习惯性咖啡摄入量与认知能力下降之间的关系，使用综合神经心理学电池对来自澳大利亚影像、生物标志物和生活方式 (AIBL) 研究的 227 名认知正常老年人进行了为期 126 个月的评估。在一部分个体中，我们还研究了 126 个月内习惯性咖啡摄入量与大脑 Aβ-淀粉样蛋白积累 (n = 60) 和脑容量 (n = 51) 之间的关系。结果：在 126 个月内，较高的基线咖啡摄入量与执行功能、注意力和 AIBL 临床前 AD 认知综合指标（PACC；可靠地测量高危认知正常人群认知衰退的最初迹象）的认知衰退速度较慢相关，并且在 126 个月内，转变为轻度认知障碍或 AD 状态的可能性较低。较高的基线咖啡摄入量还与 126 个月内 Aβ-淀粉样蛋白积累较慢有关，并且在同一时间段内进展为“中度”、“高”或“极高”Aβ-淀粉样蛋白负担状态的风险较低。咖啡摄入量与总灰质、白质或海马体积萎缩之间没有关联。讨论：我们的结果进一步支持这样的假设：咖啡摄入量可能是 AD 的保护因素，增加咖啡摄入量可能通过减缓大脑 Aβ-淀粉样蛋白积累来减少认知能力下降，从而减轻 Aβ-淀粉样蛋白介导的氧化应激和炎症过程相关的神经毒性。需要进一步调查来评估是否可以将咖啡摄入量作为一种可改变的生活方式因素纳入其中，以延缓 AD 的发病。
Background: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any such associations. Methods: The aim of the current study was to investigate the relationship between self-reported habitual coffee intake, and cognitive decline assessed using a comprehensive neuropsychological battery in 227 cognitively normal older adults from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study, over 126 months. In a subset of individuals, we also investigated the relationship between habitual coffee intake and cerebral Aβ-amyloid accumulation (n = 60) and brain volumes (n = 51) over 126 months. Results: Higher baseline coffee consumption was associated with slower cognitive decline in executive function, attention, and the AIBL Preclinical AD Cognitive Composite (PACC; shown reliably to measure the first signs of cognitive decline in at-risk cognitively normal populations), and lower likelihood of transitioning to mild cognitive impairment or AD status, over 126 months. Higher baseline coffee consumption was also associated with slower Aβ-amyloid accumulation over 126 months, and lower risk of progressing to “moderate,” “high,” or “very high” Aβ-amyloid burden status over the same time-period. There were no associations between coffee intake and atrophy in total gray matter, white matter, or hippocampal volume. Discussion: Our results further support the hypothesis that coffee intake may be a protective factor against AD, with increased coffee consumption potentially reducing cognitive decline by slowing cerebral Aβ-amyloid accumulation, and thus attenuating the associated neurotoxicity from Aβ-amyloid-mediated oxidative stress and inflammatory processes. Further investigation is required to evaluate whether coffee intake could be incorporated as a modifiable lifestyle factor aimed at delaying AD onset.
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影响因子：
29
作者：
Donohue, Michael C.;Sperling, Reisa A.;Salmon, David P.;Rentz, Dorene M.;Raman, Rema;Thomas, Ronald G.;Weiner, Michael;Aisen, Paul S.
通讯作者：
Aisen, Paul S.
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作者：
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
5.7
作者：
Bourgeat, Pierrick;Dore, Vincent;Rowe, Christopher C.
通讯作者：
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8.8
作者：
Chu, Yi-Fang;Chang, Wen-Han;Cheng, Irene H.
通讯作者：
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