Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder.
Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder.
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DOI：
10.3390/ijms19061740
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发表时间：
2018-06-12
影响因子：
5.6
通讯作者：
Rupprecht R
中科院分区：
文献类型：
--
作者：
Baghai TC;Varallo-Bedarida G;Born C;Häfner S;Schüle C;Eser D;Zill P;Manook A;Weigl J;Jooyandeh S;Nothdurfter C;von Schacky C;Bondy B;Rupprecht R
背景：心血管疾病(CVD)和严重抑郁障碍(MDD)是世界范围内导致过早死亡和残疾的最常见疾病。行为和免疫学变量影响这两种疾病的病理生理学。因此，我们确定了心血管疾病中MDD的频率和严重程度，并研究了无CVD或其他躯体疾病的MDD是否会影响心血管风险的经典和炎性生物标志物。此外，我们还研究了促炎细胞因子对抗抑郁药物治疗结果的影响。方法：采用病例对照设计，研究对象为310名成人(无心血管疾病的MDD患者、心血管疾病患者，以及心脏病和精神健康的对照组)。MDD患者在一所精神科大学医院入院后被招募。主要预后标准为临床抑郁评分(HAM-D量表)、生命体征、经典心血管危险因素和炎症生物标志物，比较MDD患者和健康对照组之间的差异。结果：我们发现MDD患者心血管风险增加。未经治疗的高血压前期和代谢综合征的体征在MDD中被检测到。高敏C反应蛋白(HsCRP)、促炎性急性期细胞因子白细胞介素1β(IL-1β)和白细胞介素6(IL-6)等炎症标志物的显著升高突出了健康的MDD患者心血管风险的增加。令人惊讶的是，治疗前高炎症标志物与更好的临床结果和更快的缓解有关。心脑血管疾病患者MDD发生率较高。结论：MDD患者具有患心血管疾病的特殊风险。除了传统危险因素外，有必要对MDD的心血管风险进行精确检测，以便对这两种情况进行有效的预防和治疗。未来对预防性干预的研究可能有助于为MDD和CVD的预防性治疗提供依据。此外，CVD患者发生MDD的风险很高，并强调了临床关注的必要性。
Background: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome. Methods: In a case-control design, 310 adults (MDD patients without CVD, CVD patients, and cardiologically and psychiatrically healthy matched controls) were investigated. MDD patients were recruited after admission in a psychiatric university hospital. Primary outcome criteria were clinical depression ratings (HAM-D scale), vital signs, classical cardiovascular risk factors and inflammatory biomarkers which were compared between MDD patients and healthy controls. Results: We detected an enhanced cardiovascular risk in MDD. Untreated prehypertension and signs directing to a metabolic syndrome were detected in MDD. Significantly higher inflammatory biomarkers such as the high sensitivity C-reaktive protein (hsCRP) and proinflammatory acute phase cytokines interleukine-1β (IL-1β) and interleukine-6 (IL-6) underlined the higher cardiovascular risk in physically healthy MDD patients. Surprisingly, high inflammation markers before treatment were associated with better clinical outcome and faster remission. The rate of MDD in CVD patients was high. Conclusions: Patients suffering from MDD are at specific risk for CVD. Precise detection of cardiovascular risks in MDD beyond classical risk factors is warranted to allow effective prophylaxis and treatment of both conditions. Future studies of prophylactic interventions may help to provide a basis for prophylactic treatment of both MDD and CVD. In addition, the high risk for MDD in CVD patients was confirmed and underlines the requirement for clinical attention.
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影响因子：
37.8
作者：
Barefoot, JC;Schroll, M
通讯作者：
Schroll, M
影响因子：
--
作者：
Lederbogen, F;Deuschle, M;Heuser, I
通讯作者：
Heuser, I
影响因子：
2.8
作者：
KANNEL, WB;MCGEE, D;GORDON, T
通讯作者：
GORDON, T
影响因子：
7.8
作者：
Leonard, BE
通讯作者：
Leonard, BE
DOI：
10.1177/039463200802100208
发表时间：
2008-04-01
影响因子：
3.5
作者：
De Berardis, D.;Conti, C. M.;Ferro, F. M.
通讯作者：
Ferro, F. M.