Differences in incidence and trends of haematological malignancies in Japan and the United States.
Differences in incidence and trends of haematological malignancies in Japan and the United States.
复制标题
日本和美国血液学恶性肿瘤的发病率和趋势差异。
DOI：
10.1111/bjh.12659
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发表时间：
2014-02
影响因子：
6.5
通讯作者：
Matsuo K
中科院分区：
文献类型：
--
作者：
Chihara D;Ito H;Matsuda T;Shibata A;Katsumi A;Nakamura S;Tomotaka S;Morton LM;Weisenburger DD;Matsuo K
恶性疾病的发病率反映了一个群体的遗传和累积暴露于环境的程度。因此，评估疾病在不同人群中的发病率和趋势可能有助于深入了解其病因和发病机制。为了根据特定亚型评价血液系统恶性肿瘤的发病率，我们使用了1993年至2008年日本（N = 125 148）和美国（US; N = 172 925）基于人群的登记数据。日本血液系统恶性肿瘤的年龄校正发生率约为美国的一半，但一直显著增加，而美国未观察到显著变化[年百分比变化（95%C置信区间）：日本，+2统计学4%（1·7，3·1）;美国，+0统计学1%（−0·1，0·2）]。霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）的发病率差异最大，其中慢性淋巴细胞白血病、HL-结节性硬化、蕈样肉芽肿和皮肤T细胞淋巴瘤的发病率差异最显著。HL和NHL在日本大幅增加，但在美国没有，这表明环境暴露，如生活方式的西化可能导致这种增加。特定亚型的发病率和趋势差异也显示出亚型之间的显著对比，这反过来可能为未来疾病病因学提供重要的新见解。
The incidence of a malignant disease reflects the genetic and cumulative exposure to the environment of a population. Therefore, evaluation of the incidence and trends of a disease in different populations may provide insights into its aetiology and pathogenesis. To evaluate the incidence of haematological malignancies according to specific subtypes, we used population-based registry data in Japan (N = 125 148) and the United States (US; N = 172 925) from 1993 to 2008. The age-adjusted incidence of haematological malignancies in Japan was approximately one-half that in the US but has been increasing significantly, whereas no significant change was seen in the US [annual percent change (95% C confidence interval): Japan, +2·4% (1·7, 3·1); US, +0·1% (−0·1, 0·2)]. Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) showed the largest differences in incidence, with the most remarkable differences observed for chronic lymphocytic leukaemia, HL-nodular sclerosis, mycosis fungoides and cutaneous T-cell lymphoma. HL and NHL are increasing substantially in Japan but not in the US, suggesting that environmental exposures, such as Westernization of the life style may be causing this increase. Differences in the incidence and trends for specific subtypes also showed a marked contrast across subtypes, which, in turn, may provide significant new insights into disease aetiology in the future.
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影响因子：
2.6
作者：
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通讯作者：
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Rothman N
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作者：
Anderson, JR;Armitage, JO;Weisenburger, DD
通讯作者：
Weisenburger, DD