Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-κB signaling pathway to attenuate ulcerative colitis.
Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-κB signaling pathway to attenuate ulcerative colitis.
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洛根碱抑制巨噬细胞M1极化并调节sirt1/NF-κB信号通路以缓解溃疡性结肠炎。
DOI：
10.1080/21655979.2020.1774992
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发表时间：
2020-12
期刊：
影响因子：
4.9
通讯作者：
Gong J
中科院分区：
文献类型：
--
作者：
Liu S;Shen H;Li J;Gong Y;Bao H;Zhang J;Hu L;Wang Z;Gong J
Loganin, a major bioactive iridoid glycoside derived from Cornus officinalis, exerts different beneficial biological properties. Recently, loganin has been reported to exhibit potential anti-inflammatory effects in the intestinal tissues, while the detailed mechanisms remain elusive. This study aimed to investigate whether loganin could inhibit the inflammatory response in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and to explore possible molecular mechanisms involved in this process. Results showed that oral administration of loganin significantly decreased body weight loss, disease activity index, colon shortening, myeloperoxidase (MPO) activity and pathologic abnormalities in UC mice. Loganin obviously inhibited the mRNA and protein levels of IL-6, TNF-α and IL-1β in colon tissues from UC mice. Furthermore, loganin remarkably reduced macrophage M1 polarization in UC mice evidenced by reduced the number of F4/80 and iNOS dual-stained M1 macrophages, and the expression of M1 macrophage-related pro-inflammatory chemokines/cytokines including MCP-1, CXCL10 as well as COX-2. Further investigation showed that loganin upregulated the mRNA and protein levels of Sirt1, with the inhibition of NF-κB-p65 acetylation in colon tissues from UC mice. Moreover, Sirt1-specific inhibitor Ex527 administration abolished the anti-inflammatory and anti-macrophage M1 polarization effects of loganin in UC. Thus, loganin could inhibit M1 macrophage-mediated inflammation and modulate Sirt1/NF-κB signaling pathway to attenuate DSS-induced UC. Loganin was considered as a viable natural strategy in the treatment of UC.
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影响因子：
5.6
作者：
Wang K;Li YF;Lv Q;Li XM;Dai Y;Wei ZF
通讯作者：
Wei ZF
影响因子：
4.3
作者：
Jaguin, Marie;Houlbert, Noemie;Lecureur, Valerie
通讯作者：
Lecureur, Valerie
DOI：
10.1038/nri3073
发表时间：
2011-10-14
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
168.9
作者：
Ordas, Ingrid;Eckmann, Lars;Sandborn, William J.
通讯作者：
Sandborn, William J.
影响因子：
11.4
作者：
Chen, LF;Mu, YJ;Greene, WC
通讯作者：
Greene, WC