Establishment and resilience of transplanted gut microbiota in aged mice.
Establishment and resilience of transplanted gut microbiota in aged mice.
复制标题
老年小鼠移植肠道微生物群的建立和恢复能力
DOI：
10.1016/j.isci.2021.103654
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发表时间：
2022-01-21
期刊：
影响因子：
5.8
通讯作者：
Dai L
中科院分区：
文献类型：
--
作者：
Wang Y;Tang J;Lv Q;Tan Y;Dong X;Liu H;Zhao N;He Z;Kou Y;Tan Y;Liu XA;Wang L;Liu YY;Dai L
维持健康和有弹性的肠道微生物区系对老年人的生活质量和健康寿命至关重要。粪便微生物区系移植(FMT)越来越多地被用于恢复健康的肠道微生物区系。我们系统地研究了老年受者自体与异体FMT后移植微生物区系的建立和恢复能力。老龄小鼠(20个月龄)的肠道微生物区系在抗生素治疗后8周内未能通过自发恢复恢复其原始多样性和组成；相反，使用自体或异源(2个月龄来自不同供应商)供体的FMT成功地促进了恢复，建立了供体样微生物区系状态，并影响了宿主基因表达谱。此外，与自体FMT相比，异种FMT建立的移植微生物群在化学诱导的结肠炎中没有弹性。我们的发现强调了监测移植肠道微生物区系长期稳定性的必要性，并在必要时进行多次FMT。老年小鼠微生物区系在抗生素治疗后恢复缓慢自体和异种FMT促进老年小鼠微生物区系的恢复FMT影响肠道元基因组和结肠基因表达的长期动态平衡异种FMT后建立的微生物群对结肠炎微生物学没有弹性
The maintenance of healthy and resilient gut microbiota is critical for the life quality and healthspan of the elderly. Fecal microbiota transplantation (FMT) has been increasingly used to restore healthy gut microbiota. We systemically studied the establishment and resilience of transplanted microbiota after autologous versus heterologous FMT in aged recipients. Gut microbiota of aged mice (20 months old) failed to restore their original diversity and composition over 8 weeks via spontaneous recovery after antibiotics treatment; in contrast, FMT using either autologous or heterologous (2 months old from a different vendor) donors facilitated the recovery successfully, established donor-like microbiota states, and affected host gene expression profile. Furthermore, the transplanted microbiota established by heterologous FMT is not resilient during chemical-induced colonic inflammation, in contrast to that of autologous FMT. Our findings highlighted the need to monitor the long-term stability of transplanted gut microbiota and to perform multiple FMT when necessary. Aged mice microbiota restores slowly after antibiotics treatment Both autologous and heterologous FMT facilitate microbiota restoration in aged mice FMT affects long-term homeostasis of gut metagenome and colon gene expression Established microbiota after heterologous FMT is not resilient against colitis Microbiology; Microbiome
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
15.5
作者：
D'Amato A;Di Cesare Mannelli L;Lucarini E;Man AL;Le Gall G;Branca JJV;Ghelardini C;Amedei A;Bertelli E;Regoli M;Pacini A;Luciani G;Gallina P;Altera A;Narbad A;Gulisano M;Hoyles L;Vauzour D;Nicoletti C
通讯作者：
Nicoletti C
影响因子：
3.7
作者：
Bakker, Guido J.;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max
影响因子：
82.9
作者：
Barcena, Clea;Valdes-Mas, Rafael;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos
DOI：
10.1056/nejmra0707500
发表时间：
2008-10-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kelly, Ciaran P;LaMont, J Thomas
通讯作者：
LaMont, J Thomas