Comparative genomics of the mimicry switch in Papilio dardanus.
Comparative genomics of the mimicry switch in Papilio dardanus.
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DOI：
10.1098/rspb.2014.0465
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发表时间：
2014-07-22
期刊：
影响因子：
--
通讯作者：
Vogler AP
中科院分区：
文献类型：
--
作者：
Timmermans MJ;Baxter SW;Clark R;Heckel DG;Vogel H;Collins S;Papanicolaou A;Fukova I;Joron M;Thompson MJ;Jiggins CD;ffrench-Constant RH;Vogler AP
非洲模拟燕尾蝶（Papilio dardanus）是进化遗传学的教科书范例。经典的育种实验已经表明，在这种多态性的蝙蝠模拟翼模式的变化是由多等位基因H基因座，控制一组不同的模拟表型。利用细菌人工染色体（BAC）测序，重组分析和比较基因组学，我们表明，H共分离的间隔小于500 kb，是共线的两个其他鳞翅目基因组，并包含24个基因，包括转录因子基因enrailed（en）和invected（inv）。H位于保守基因顺序的区域，这反对在假设的多基因拟态位点的进化中基因组易位的任何作用。P. dardanus的自然种群显示出特定形态与单核苷酸多态性（SNP）的显着关联，集中在en。此外，H区的SNP变异揭示了单独在en基因中的非中性分子进化的证据。我们发现证据的复制潜在的驱动物理约束重组的兰博尼形态。在其他变体中不同基因之间缺乏完美的连锁不平衡表明H仅限于en的调控和编码区中的核苷酸位置。因此，我们的研究结果支持的假设，一个单一的基因在P.dardanus翅型的变化。
The African Mocker Swallowtail, Papilio dardanus, is a textbook example in evolutionary genetics. Classical breeding experiments have shown that wing pattern variation in this polymorphic Batesian mimic is determined by the polyallelic H locus that controls a set of distinct mimetic phenotypes. Using bacterial artificial chromosome (BAC) sequencing, recombination analyses and comparative genomics, we show that H co-segregates with an interval of less than 500 kb that is collinear with two other Lepidoptera genomes and contains 24 genes, including the transcription factor genes engrailed (en) and invected (inv). H is located in a region of conserved gene order, which argues against any role for genomic translocations in the evolution of a hypothesized multi-gene mimicry locus. Natural populations of P. dardanus show significant associations of specific morphs with single nucleotide polymorphisms (SNPs), centred on en. In addition, SNP variation in the H region reveals evidence of non-neutral molecular evolution in the en gene alone. We find evidence for a duplication potentially driving physical constraints on recombination in the lamborni morph. Absence of perfect linkage disequilibrium between different genes in the other morphs suggests that H is limited to nucleotide positions in the regulatory and coding regions of en. Our results therefore support the hypothesis that a single gene underlies wing pattern variation in P. dardanus.
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影响因子：
3.3
作者：
CLARKE, CA;SHEPPARD, PM
通讯作者：
SHEPPARD, PM
影响因子：
64.8
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Joron, Mathieu;Frezal, Lise;Jones, Robert T.;Chamberlain, Nicola L.;Lee, Siu F.;Haag, Christoph R.;Whibley, Annabel;Becuwe, Michel;Baxter, Simon W.;Ferguson, Laura;Wilkinson, Paul A.;Salazar, Camilo;Davidson, Claire;Clark, Richard;Quail, Michael A.;Beasley, Helen;Glithero, Rebecca;Lloyd, Christine;Sims, Sarah;Jones, Matthew C.;Rogers, Jane;Jiggins, Chris D.;Ffrench-Constant, Richard H.
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Ffrench-Constant, Richard H.
影响因子：
64.8
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通讯作者：
Jiggins, Chris D.
影响因子：
5.8
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Gonzalez, Juan R.;Armengol, Lluis;Moreno, Victor
通讯作者：
Moreno, Victor
影响因子：
64.8
作者：
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通讯作者：
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