Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.
Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.
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膀胱癌的磁液高温：一项临床前剂量测定研究。
DOI：
10.3109/02656736.2013.834384
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Dewhirst MW
中科院分区：
文献类型：
--
作者：
Oliveira TR;Stauffer PR;Lee CT;Landon CD;Etienne W;Ashcraft KA;McNerny KL;Mashal A;Nouls J;Maccarini PF;Beyer WF Jr;Inman B;Dewhirst MW
本文介绍了一种临床前研究的可行性热疗治疗膀胱癌磁流体热疗（MFH），通过分析纳米粒子加热在大鼠膀胱模型的热剂量学。向25只雌性大鼠的膀胱中滴入基于磁铁矿的纳米颗粒，并使用新型小动物磁场施加器（Actium Biosystems，Boulder，CO）诱导高热。我们的目标是在<10 min内将膀胱腔温度升高至42°C，并保持该温度60 min。使用7个光纤探针（OpSens Technologies，魁北克，加拿大）测量膀胱腔内和整个大鼠的温度。使用MRI分析来确认导管插入方法在膀胱内递送和维持各种纳米颗粒体积的有效性。热剂量测量记录了各种纳米颗粒暴露条件下大鼠组织的温升。热剂量测定数据表明，我们能够以≥1°C/min的速度将大鼠膀胱腔的温度升高并控制在42°C的稳态，同时对周围正常组织的加热最小。MRI扫描证实了在整个膀胱中均匀的纳米颗粒分布。这些数据表明，我们的具有基于磁铁矿的纳米颗粒的MFH系统提供了对大鼠膀胱腔的良好局部加热，有效控制膀胱中的温度和对周围组织的最小加热。
This paper describes a preclinical investigation of the feasibility of thermotherapy treatment of bladder cancer with Magnetic Fluid Hyperthermia (MFH), performed by analyzing the thermal dosimetry of nanoparticle heating in a rat bladder model. The bladders of twenty-five female rats were instilled with magnetite-based nanoparticles, and hyperthermia was induced using a novel small animal magnetic field applicator (Actium Biosystems, Boulder, CO). We aimed to increase the bladder lumen temperature to 42°C in <10 min and maintain that temperature for 60 min. Temperatures were measured within the bladder lumen and throughout the rat with seven fiberoptic probes (OpSens Technologies, Quebec, Canada). An MRI analysis was used to confirm the effectiveness of the catheterization method to deliver and maintain various nanoparticle volumes within the bladder. Thermal dosimetry measurements recorded the temperature rise of rat tissues for a variety of nanoparticle exposure conditions. Thermal dosimetry data demonstrated our ability to raise and control the temperature of rat bladder lumen ≥1°C/min to a steady-state of 42°C with minimal heating of surrounding normal tissues. MRI scans confirmed the homogenous nanoparticle distribution throughout the bladder. These data demonstrate that our MFH system with magnetite-based nanoparticles provide well-localized heating of rat bladder lumen with effective control of temperature in the bladder and minimal heating of surrounding tissues.
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影响因子：
4.6
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