Interfacing Living and Synthetic Cells as an Emerging Frontier in Synthetic Biology.
Interfacing Living and Synthetic Cells as an Emerging Frontier in Synthetic Biology.
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DOI：
10.1002/anie.202006941
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发表时间：
2021-03-08
期刊：
影响因子：
--
通讯作者：
Elani Y
中科院分区：
文献类型：
--
作者：
Elani Y
用无生命的分子构件构建人造细胞是我们这个时代的重大挑战之一。除了用作简化的细胞模型来破译生命的规则外，人造细胞还有可能被设计成微型机器，部署在许多临床和工业应用中。与重新设计活的生物细胞相比，从头开始设计人造细胞的吸引力是多种多样的。然而，很明显，人工细胞目前还无法与生物细胞的能力和行为复杂性相媲美。考虑到这一点，合成生物学社区的许多人开始问：是否有可能将生物细胞和人工细胞结合在一起，创造出利用两者优势的混合生命/合成系统？本文将讨论这种细胞仿生学方法背后的动机，在这种方法中，通过连接自上而下和自下而上的合成生物学，模糊了生物和非生物物质之间的界限。它详细介绍了这个新兴领域的游戏状态，并介绍了已经出现的三种通用杂交模式。这篇综述概述了细胞仿生学研究领域的现状，生物细胞和合成细胞杂交，从而弥合了生物/非生物的鸿沟。
The construction of artificial cells from inanimate molecular building blocks is one of the grand challenges of our time. In addition to being used as simplified cell models to decipher the rules of life, artificial cells have the potential to be designed as micromachines deployed in a host of clinical and industrial applications. The attractions of engineering artificial cells from scratch, as opposed to re‐engineering living biological cells, are varied. However, it is clear that artificial cells cannot currently match the power and behavioural sophistication of their biological counterparts. Given this, many in the synthetic biology community have started to ask: is it possible to interface biological and artificial cells together to create hybrid living/synthetic systems that leverage the advantages of both? This article will discuss the motivation behind this cellular bionics approach, in which the boundaries between living and non‐living matter are blurred by bridging top‐down and bottom‐up synthetic biology. It details the state of play of this nascent field and introduces three generalised hybridisation modes that have emerged. This Minireview outlines the state of play in the research area of cellular bionics, where biological and synthetic cells are hybridised, thus bridging the living/non‐living divide.
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影响因子：
21.8
作者：
Adamala KP;Martin-Alarcon DA;Guthrie-Honea KR;Boyden ES
通讯作者：
Boyden ES
影响因子：
4.6
作者：
Elani Y;Trantidou T;Wylie D;Dekker L;Polizzi K;Law RV;Ces O
通讯作者：
Ces O
DOI：
10.1007/s11693-010-9066-z
发表时间：
2011-06-01
期刊：
Systems and synthetic biology
影响因子：
--
作者：
Amidi, Maryam;de Raad, Markus;Mastrobattista, Enrico
通讯作者：
Mastrobattista, Enrico
影响因子：
16.6
作者：
Elani, Yuval;Law, Robert V.;Ces, Oscar
通讯作者：
Ces, Oscar
影响因子：
15
作者：
Deng, Nan-Nan;Yelleswarapu, Maaruthy;Huck, Wilhelm T. S.
通讯作者：
Huck, Wilhelm T. S.