Enhanced choice for viewing cocaine pictures in cocaine addiction.
Enhanced choice for viewing cocaine pictures in cocaine addiction.
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DOI：
10.1016/j.biopsych.2009.02.015
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发表时间：
2009-07-15
影响因子：
10.6
通讯作者：
Goldstein, Rita Z.
中科院分区：
文献类型：
--
作者：
Moeller, Scott J.;Maloney, Thomas;Parvaz, Muhammad A.;Dunning, Jonathan P.;Alia-Klein, Nelly;Woicik, Patricia A.;Hajcak, Greg;Telang, Frank;Wang, Gene-Jack;Volkow, Nora D.;Goldstein, Rita Z.
关键词：
可卡因使用障碍（CUD）患者选择可卡因而不是非药物奖励。在两个新设计的实验室任务与图片，我们记录这种修改后的选择以外的可卡因管理模式。选择观看可卡因，愉快的，不愉快的，或中性的图片-下明确的意外事件（其中选择是在两个完全可见的并排图像之间）和下更隐的意外事件（其中选择是隐藏在翻转卡下的图片之间）-在20个CUD和20个匹配的健康对照进行了检查。受试者还提供了自我报告的评级，每张图片的愉快和兴奋。在这两种情况下，CUD选择查看更多的可卡因图片比对照组，组的差异并没有完全解释的自我报告的图片评级。此外，而CUD的选择观看可卡因图片超过选择观看不愉快的图片（但没有超过选择观看愉快的图片，在他们的自我报告的评级相反），健康的控制避免观看可卡因图片频繁，甚至超过，不愉快的图片。最后，具有最多可卡因观看选择的CUD，即使直接与令人愉快的图片的选择相比，也报告了最近最频繁的可卡因使用。可卡因成瘾中与药物相关的选择增强，即使是非药理学（图像）刺激也可以证明。这种选择，这是调制的替代刺激，部分超越自我报告（可能表明可卡因成瘾的断开之间的自我报告和客观行为），以提供一个客观的标记成瘾的严重程度。需要进行神经影像学研究，以确定这种增强的可卡因相关选择的神经基础。
Individuals with cocaine use disorder (CUD) chose cocaine over non-drug rewards. In two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm. Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures - under explicit contingencies (where choice was made between two fully-visible side-by-side images) and under more implicit contingencies (where selections were made between pictures hidden under flipped-over cards) - was examined in 20 CUD and 20 matched healthy controls. Subjects also provided self-reported ratings of each picture’s pleasantness and arousal. Under both contingencies, CUD chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Further, whereas CUD’s choice for viewing cocaine pictures exceeded choice for viewing unpleasant pictures (but did not exceed choice for viewing pleasant pictures, in contrast to their self-reported ratings), healthy controls avoided viewing cocaine pictures as frequently as, or even more than, unpleasant pictures. Finally, CUD with the most cocaine viewing selections, even when directly compared to selections of the pleasant pictures, also reported the most frequent recent cocaine use. Enhanced drug-related choice in cocaine addiction can be demonstrated even for non-pharmacological (pictorial) stimuli. This choice, which is modulated by alternative stimuli, partly transcends self-reports (possibly indicative of a disconnect in cocaine addiction between self-reports and objective behavior) to provide an objective marker of addiction severity. Neuroimaging studies are needed to establish the neural underpinnings of such enhanced cocaine-related choice.
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