Chronic manganese exposure impairs visuospatial associative learning in non-human primates.
Chronic manganese exposure impairs visuospatial associative learning in non-human primates.
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DOI：
10.1016/j.toxlet.2013.06.211
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发表时间：
2013-08-14
影响因子：
3.5
通讯作者：
Guilarte, T. R.
中科院分区：
文献类型：
--
作者：
Schneider, J. S.;Williams, C.;Ault, M.;Guilarte, T. R.
锰（Mn）是必需的微量金属营养素，然而，过量的Mn可具有神经毒性。成年人慢性环境或职业暴露于锰导致神经心理功能障碍的程度是相当感兴趣的。慢性锰暴露后的神经心理功能障碍的描述有些不一致，虽然，可能是由于不同的措施，在不同的人群中的暴露，复杂的混合暴露和差异的因素，在神经心理测试管理。我们先前描述了上调的mRNA表达的淀粉样β（A-β）受体样蛋白1（APLP 1）和存在的A-β弥漫性斑块在额叶皮质锰暴露的猴子。本研究探讨锰诱导的变化表现成对关联学习（PAL）的任务，已被建议作为临床前阿尔茨海默氏病的标志。在锰暴露开始后，这项任务的性能方面受到影响。因此，PAL性能可能是早期，临床前检测早期痴呆症的敏感和有价值的工具，它也可能是一个敏感的工具，用于检测认知功能障碍锰暴露。目前的认知数据，结合我们以前的研究结果，表明额叶皮层可能是一个特别敏感的目标锰对认知的影响，慢性锰暴露可能会启动或加速一个过程，可能导致或易患阿尔茨海默氏症样的病理和认知功能障碍。
Manganese (Mn) is an essential trace metal nutrient, however, excess Mn can be neurotoxic. The degree to which chronic environmental or occupational exposures to Mn in adults cause neuropsychological dysfunction is of considerable interest. Descriptions of neuropsychological dysfunction following chronic Mn exposure have been somewhat inconsistent though, likely owing to different measures of exposure in different populations, complicated by factors of mixed exposures and differences in neuropsychological tests administered. We previously described up-regulation of the mRNA expression for amyloid-beta (A-beta) precursor-like protein 1 (APLP1) and the presence of A-beta diffuse plaques in frontal cortex of Mn-exposed monkeys. The present study examined Mn-induced changes in performance on a paired associate learning (PAL) task that has been suggested as a marker for preclinical Alzheimer’s disease. Aspects of performance of this task were affected early following initiation of Mn exposure. Thus, PAL performance may be a sensitive and valuable tool for the early, preclinical detection of incipient dementia and it may also be a sensitive tool for detecting cognitive dysfunction from Mn exposure. The current cognitive data, combined with our previous findings, suggest that frontal cortex may be a particularly sensitive target for the effects of Mn on cognition and that chronic Mn exposure may initiate or accelerate a process that could lead to or predispose to Alzheimer’s like pathology and cognitive dysfunction.
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影响因子：
3.4
作者：
Laohaudomchok W;Lin X;Herrick RF;Fang SC;Cavallari JM;Shrairman R;Landau A;Christiani DC;Weisskopf MG
通讯作者：
Weisskopf MG
影响因子：
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作者：
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通讯作者：
Wedler, F C
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Schneider, Jay S.
影响因子：
4.9
作者：
Bowler, Rosemarie M.;Roels, Harry A.;Doty, Richard L.
通讯作者：
Doty, Richard L.