Vaginal microbiome: rethinking health and disease.
Vaginal microbiome: rethinking health and disease.
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DOI：
10.1146/annurev-micro-092611-150157
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发表时间：
2012
影响因子：
10.5
通讯作者：
Ravel J
中科院分区：
文献类型：
--
作者：
Ma B;Forney LJ;Ravel J
阴道微生物群与宿主形成互利关系，对健康和疾病有重大影响。近年来，由于研究人员使用基于16S核糖体RNA（rRNA）基因序列分析的不依赖培养的方法，我们对阴道细菌群落组成和结构的理解显着扩大。在无症状的健康女性中，存在几种阴道微生物群，大多数通常由乳杆菌属物种占主导地位，而其他则包括各种厌氧微生物。细菌性阴道病是最常见的阴道疾病，其特征是“正常”阴道微生物平衡的破坏。更好地了解“正常”和“健康”的阴道生态系统，这是基于其“真正”的功能，而不仅仅是其组成，将有助于更好地定义健康，进一步改善疾病诊断以及开发更个性化的方案，以促进健康和治疗疾病。
Vaginal microbiota form a mutually beneficial relationship with their host and have major impact on health and disease. In recent years our understanding of vaginal bacterial community composition and structure has significantly broadened as a result of investigators using cultivation-independent methods based on the analysis of 16S ribosomal RNA (rRNA) gene sequences. In asymptomatic, otherwise healthy women, several kinds of vaginal microbiota exist, the majority often dominated by species of Lactobacillus, while others comprise a diverse array of anaerobic microorganisms. Bacterial vaginosis is the most common vaginal conditions and is vaguely characterized as the disruption of the equilibrium of the ‘normal’ vaginal microbiots. A better understanding of ‘normal’ and ‘healthy’ vaginal ecosystems that is based on its ‘true’ function and not simply on its composition would help better define health and further improve disease diagnostics as well as the development of more personalized regimens to promote health and treat diseases.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
11.4
作者：
EVANS, M;DYSON, P
通讯作者：
DYSON, P
影响因子：
6.1
作者：
Boskey, ER;Cone, RA;Moench, TR
通讯作者：
Moench, TR
影响因子：
3.6
作者：
Brotman RM;Ravel J;Cone RA;Zenilman JM
通讯作者：
Zenilman JM
影响因子：
11.8
作者：
Cherpes, TL;Meyn, LA;Hillier, SL
通讯作者：
Hillier, SL