Infiltration of T lymphocytes and expression of icam-1 in the hippocampus of patients with hippocampal sclerosis.
Infiltration of T lymphocytes and expression of icam-1 in the hippocampus of patients with hippocampal sclerosis.
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DOI：
10.1267/ahc.10022
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发表时间：
2010-12-29
影响因子：
2.4
通讯作者：
Tooyama I
中科院分区：
文献类型：
--
作者：
Nakahara H;Konishi Y;Beach TG;Yamada N;Makino S;Tooyama I
我们和其他人之前已经证明，反应性小胶质细胞在癫痫患者的海马区表达主要组织相容性复合体(MHC)I类和II类抗原。尽管MHC糖蛋白作为T淋巴细胞的限制性元件，但关于T淋巴细胞在海马区硬化中的作用的信息却很少。在本研究中，我们研究了4例癫痫伴海马区硬化症患者和4例无神经系统疾病的对照患者海马区T淋巴细胞的分布。对照组大鼠海马区未见CD8或CD4阳性T淋巴细胞。相比之下，CD8和CD4阳性T淋巴细胞已经渗透到海马区硬化症患者的海马区。此外，细胞间黏附分子-1在海马区的表达呈弥漫性上调。这些结果表明T淋巴细胞的浸润参与了海马区硬化的病理过程。
We and others have previously shown that reactive microglia express the major histocompatibility complex (MHC) class I and class II antigens in the hippocampus of patients suffering from epilepsy. Although the MHC glycoproteins serve as restriction elements for T lymphocytes, there is little information available regarding T lymphocytes in hippocampal sclerosis. In the present study, we investigated T lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. No CD8- or CD4-positive T lymphocytes were seen in hippocampi from the control cases. In contrast, CD8- and CD4-positive T lymphocytes had infiltrated into the hippocampi of patients with hippocampal sclerosis. In addition, expression of intercellular adhesion molecule-1 was diffusely upregulated in the hippocampi with hippocampal sclerosis. These results indicate that T lymphocyte infiltration is involved in the pathology of hippocampal sclerosis.
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影响因子：
12.7
作者：
Uchikado, H;Akiyama, H;Kosaka, K
通讯作者：
Kosaka, K
影响因子：
4.2
作者：
ROGERS, J;LUBERNAROD, J;CIVIN, WH
通讯作者：
CIVIN, WH
影响因子：
2.9
作者：
TOOYAMA, I;KIMURA, H;MCGEER, PL
通讯作者：
MCGEER, PL
影响因子：
4.2
作者：
AKIYAMA, H;ITAGAKI, S;MCGEER, PL
通讯作者：
MCGEER, PL
影响因子：
6.2
作者：
MCGEER, PL;KAWAMATA, T;MCGEER, EG
通讯作者：
MCGEER, EG