A multivariate twin study of autistic traits in 12-year-olds: testing the fractionable autism triad hypothesis.
A multivariate twin study of autistic traits in 12-year-olds: testing the fractionable autism triad hypothesis.
复制标题
12岁儿童自闭症特征的多元双胞胎研究：测试可分离的自闭症三合会假设。
DOI：
10.1007/s10519-011-9500-3
复制
发表时间：
2012-03
影响因子：
2.6
通讯作者：
Ronald, Angelica
中科院分区：
文献类型：
--
作者：
Robinson, Elise B.;Koenen, Karestan C.;McCormick, Marie C.;Munir, Kerim;Hallett, Victoria;Happe, Francesca;Plomin, Robert;Ronald, Angelica
Autistic traits—social impairment, communication impairment, and restricted and repetitive behaviors and interests—are heritable in the general population. Previous analyses have consistently reported limited genetic and environmental overlap between autistic trait domains in samples assessed in middle childhood. Here we extend this research to parent-report data for 12-year-olds. Data from 5,944 pairs in the Twins Early Development Study were analyzed to explore the domain-specific heritability and degree of shared genetic and environmental influences across different autistic traits in the general population and among individuals scoring in the top 5% of each domain. Sex differences in the etiological estimates were also tested in these analyses. Autistic traits were moderately to highly heritable (0.58–0.88) at age 12. Bivariate genetic correlations in the full sample (0.18–0.40) and the extremes (0.24–0.67), as well as even lower unique environmental correlations, all suggested considerable fractionation of genetic and environmental influences across autistic trait domains, in line with previous findings.
登录
查看更多内容
影响因子：
10.6
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD
影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
DOI：
10.1111/j.1469-7610.2004.00266.x
发表时间：
2004-05-01
影响因子：
7.6
作者：
Constantino, JN;Gruber, CP;Przybeck, T
通讯作者：
Przybeck, T
影响因子：
2.6
作者：
DEFRIES, JC;FULKER, DW
通讯作者：
FULKER, DW
影响因子：
16.2
作者：
Levy, Dan;Ronennus, Michael;Wigler, Michael
通讯作者：
Wigler, Michael