Social appraisal in chronic psychosis: role of medial frontal and occipital networks.
Social appraisal in chronic psychosis: role of medial frontal and occipital networks.
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DOI：
10.1016/j.jpsychires.2010.08.004
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发表时间：
2011-04
影响因子：
4.8
通讯作者：
Welsh RC
中科院分区：
文献类型：
--
作者：
Taylor SF;Chen AC;Tso IF;Liberzon I;Welsh RC
精神分裂症患者经常把别人评价为具有威胁性或迫害性。为了评估精神分裂症患者的社会评价，我们用一项任务来探测大脑网络，在这项任务中，受试者判断他们是否喜欢带有情绪表情的面部刺激。我们预测，评价负面表情会让患者比对照组更投入，负面表情会与更高水平的负面情绪相关，并增加内侧额叶皮层的活动，这是一个涉及社会评价的区域。21例稳定的门诊慢性非情感性精神病患者（16例精神分裂症，5例情感性精神病）和21例健康受试者进行了功能磁共振成像。与对照受试者相比，患者的反应较慢，但在判断负价值面孔时尤其缓慢，这种缓慢与精神病患者的负面影响相关。评价激活了所有面孔效价的内侧前额叶皮层（mPFC）。对于阴性表达，患者表现出更大的激活背侧前扣带皮层（dACC）。dACC的心理生理学相互作用分析显示，对照组中的mPFC存在共同调节，患者中的mPFC显著减少，患者中的枕叶皮质存在共同调节的趋势。枕叶皮层的活动与社会适应不良和社会认知受损相关，dACC对枕叶回的共同调节与社会认知不良相关。研究结果将负面情绪的评估与内侧额叶皮层的异常激活联系起来，而这种社会认知任务的早期感觉处理与社会功能低下有关，反映了自上而下或自下而上的影响。
Persons with schizophrenia often appraise other individuals as threatening or persecutory. To evaluate social appraisal in schizophrenia, we probed brain networks with a task in which subjects judged whether or not they liked face stimuli with emotional expressions. We predicted that appraising negative expressions would engage patients, more than controls, and negative faces would be related to higher levels of negative affect and produce increased activity in the medial frontal cortex, an area involved in social appraisal. Twenty-one stable outpatients with chronic non-affective psychosis (16 schizophrenic, 5 schizoaffective) and 21 healthy subjects underwent functional magnetic resonance imaging. Compared with the control subjects, patients were slower to respond, but particularly slow when they judged negatively-valenced faces, a slowness correlated with negative affect in the psychosis patients. Appraisal activated the medial prefrontal cortex (mPFC) across all face valences. For negative expressions, patients exhibited greater activation of the dorsal anterior cingulate cortex (dACC). A psychophysiological interaction analysis of the dACC revealed co-modulation of the mPFC in controls, significantly less in patients, and a trend for co-modulation of occipital cortex in the patients. Activity in occipital cortex correlated with poor social adjustment and impaired social cognition, and co-modulation of the occipital gyrus by the dACC was correlated with poorer social cognition. The findings link appraisal of negative affect with aberrant activation of the medial frontal cortex, while early sensory processing of this social cognitive task was linked with poor social function, reflecting either top down or bottom up influences.
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作者：
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通讯作者：
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发表时间：
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影响因子：
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