Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.
Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.
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DOI：
10.1099/vir.0.047506-0
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Wang H;Yuan Z;Barnes E;Yuan M;Li C;Fu Y;Xia X;Li G;Newton PN;Vongsouvath M;Klenerman P;Pybus OG;Murphy D;Abe K;Lu L
对丙型肝炎病毒部分序列的分析揭示了许多新的6型变种，这些变种不能明确地归类，这掩盖了先前存在的亚型的特殊性。为了探索这种不确定性，我们获得了8个这样的变异体(KM35、QC273、TV257、TV476、TV533、L349、QC271和DH027)的98.0-98.8 %的全长基因组，并用系统发育分析和核苷酸相似性百分比对它们进行了表征。TV533和L349与6l亚型亲缘关系较近，QC271与6i和6J亚型亲缘关系较近，DH027与6m和6n亚型亲缘关系较近。前六个亚型定义了一个高水平的分组，包括6k和6l亚型以及相关毒株。亚型内多样性和亚型间多样性之间的阈值不明显。我们认为，如果对更多的中间变异体，如QC271和DH027进行采样，在其他地方也会看到类似的结果。
Analysis of partial hepatitis C virus sequences has revealed many novel genotype 6 variants that cannot be unambiguously classified, which obscure the distinctiveness of pre-existing subtypes. To explore this uncertainty, we obtained genomes of 98.0–98.8 % full-length for eight such variants (KM35, QC273, TV257, TV476, TV533, L349, QC271 and DH027) and characterized them using phylogenetic analyses and per cent nucleotide similarities. The former four are closely related phylogenetically to subtype 6k, TV533 and L349 to subtype 6l, QC271 to subtypes 6i and 6j, and DH027 to subtypes 6m and 6n. The former six defined a high-level grouping that comprised subtypes 6k and 6l, plus related strains. The threshold between intra- and inter-subtype diversity in this group was indistinct. We propose that similar results would be seen elsewhere if more intermediate variants like QC271 and DH027 were sampled.
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影响因子：
12.7
作者：
Xia, Xueshan;Lu, Ling;Tee, Kok Keng;Zhao, Wenhua;Wu, Jianguo;Yu, Jing;Li, Xiaojie;Lin, Yixiong;Mukhtar, Muhammad Mahmood;Hagedorn, Curt H.;Takebe, Yutaka
通讯作者：
Takebe, Yutaka
DOI：
10.1016/j.trstmh.2010.03.002
发表时间：
2010-07-01
影响因子：
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作者：
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