The phage-related chromosomal islands of Gram-positive bacteria.
The phage-related chromosomal islands of Gram-positive bacteria.
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DOI:
10.1038/nrmicro2393
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发表时间:
2010-08
期刊:
影响因子:
--
通讯作者:
Penadés JR
中科院分区:
文献类型:
--
作者:
Novick RP;Christie GE;Penadés JR
The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.
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