The phage-related chromosomal islands of Gram-positive bacteria.

The phage-related chromosomal islands of Gram-positive bacteria.
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DOI:
10.1038/nrmicro2393
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发表时间:
2010-08
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
Penadés JR
Penadés JR
中科院分区:
其他
文献类型:
--
作者:
Novick RP;Christie GE;Penadés JR

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噬菌体相关染色体岛 (PRCI) 首次在金黄色葡萄球菌中被鉴定为高度移动的超抗原编码遗传元件,称为金黄色葡萄球菌致病性岛 (SaPI)。这些元件的特点是具有一组特定的噬菌体相关功能,使它们能够利用噬菌体繁殖周期进行自身转导,并在此过程中抑制噬菌体繁殖。 SaPI 产生许多噬菌体样传染性颗粒;它们的链球菌对应物在基因调节中发挥作用,但可能不具有传染性。因此,这些元件代表噬菌体卫星或寄生虫,而不是有缺陷的噬菌体。在这篇综述中,我们讨论了 PRCIs 的共享遗传内容、它们的生命周期以及它们跨大系统发育距离转移的能力。
The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.
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