Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats.
Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats.
复制标题
DOI：
10.1016/j.resp.2009.07.015
复制
发表时间：
2009-09-30
影响因子：
2.3
通讯作者：
Liang, Xiaomin
中科院分区：
文献类型：
--
作者：
Zhang, Zhenxiong;Xu, Fadi;Zhang, Cancan;Liang, Xiaomin
Opioids can attenuate the peripheral chemoreceptor-mediated hypoxic ventilatory response (HVR) by acting on central μ-type opioid receptors. Since the medullary raphe region (MRRs) expresses abundant μ-receptors and participates in modulating HVR, we tested the role of μ-receptors within the caudal, medial, and rostral MRR (cMRR, mMRR, and rMRR) in modulating the HVR. We recorded cardiorespiratory activities and their responses to isocapnic hypoxia in anesthetized rats before and after local microinjection of DAMGO into the MRR, and intravenous administration of DAMGO (100 μg/kg) alone or coupled with a previous local injection of CTAP. Microinjecting DAMGO into the cMRR or mMRR but not the rMRR significantly attenuated the HVR. However, systemic DAMGO-induced HVR attenuation was not significantly affected by pretreating the cMRR and mMRR with CTAP. Our data suggest that cMRR and mMRR μ-receptors are capable of depressing the HVR, while their contribution to the attenuated HVR by systemic DAMGO is limited.
登录
查看更多内容
影响因子：
5.5
作者：
HOUSLEY, GD;SINCLAIR, JD
通讯作者：
SINCLAIR, JD
影响因子：
1.7
作者：
Kalyuzhny, AE;Wessendorf, MW
通讯作者：
Wessendorf, MW
影响因子：
3.3
作者：
Nattie, EE;Li, AH
通讯作者：
Li, AH
影响因子：
2.3
作者：
Colman, AS;Miller, JH
通讯作者：
Miller, JH
影响因子：
7.3
作者：
KIRBY, GC;MCQUEEN, DS
通讯作者：
MCQUEEN, DS