Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates.
Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates.
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DOI：
10.1371/journal.pone.0100218
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Misra M
中科院分区：
文献类型：
--
作者：
Singhal V;Lawson EA;Ackerman KE;Fazeli PK;Clarke H;Lee H;Eddy K;Marengi DA;Derrico NP;Bouxsein ML;Misra M
Irisin and FGF21 are novel hormones implicated in the “browning” of white fat, thermogenesis, and energy homeostasis. However, there are no data regarding these hormones in amenorrheic athletes (AA) (a chronic energy deficit state) compared with eumenorrheic athletes (EA) and non-athletes. We hypothesized that irisin and FGF21 would be low in AA, an adaptive response to low energy stores. Furthermore, because (i) brown fat has positive effects on bone, and (ii) irisin and FGF21 may directly impact bone, we hypothesized that bone density, structure and strength would be positively associated with these hormones in athletes and non-athletes. To test our hypotheses, we studied 85 females, 14–21 years [38 AA, 24 EA and 23 non-athletes (NA)]. Fasting serum irisin and FGF21 were measured. Body composition and bone density were assessed using dual energy X-ray absorptiometry, bone microarchitecture using high resolution peripheral quantitative CT, strength estimates using finite element analysis, resting energy expenditure (REE) using indirect calorimetry and time spent exercising/week by history. Subjects did not differ for pubertal stage. Fat mass was lowest in AA. AA had lower irisin and FGF21 than EA and NA, even after controlling for fat and lean mass. Across subjects, irisin was positively associated with REE and bone density Z-scores, volumetric bone mineral density (total and trabecular), stiffness and failure load. FGF21 was negatively associated with hours/week of exercise and cortical porosity, and positively with fat mass and cortical volumetric bone density. Associations of irisin (but not FGF21) with bone parameters persisted after controlling for potential confounders. In conclusion, irisin and FGF21 are low in AA, and irisin (but not FGF21) is independently associated with bone density and strength in athletes.
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影响因子：
3.7
作者：
Kim KH;Kim SH;Min YK;Yang HM;Lee JB;Lee MS
通讯作者：
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DOI：
10.1007/s00198-012-2110-y
发表时间：
2013-04
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
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DOI：
10.1139/h2012-091
发表时间：
2012-12
期刊：
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
影响因子：
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DOI：
10.1073/pnas.4.12.370
发表时间：
1918-01-01
影响因子：
11.1
作者：
Harris, JA;Benedict, FG
通讯作者：
Benedict, FG
DOI：
10.1016/j.bbrc.2013.02.019
发表时间：
2013-03-22
影响因子：
3.1
作者：
Ishida, Kazunari;Haudenschild, Dominik R.
通讯作者：
Haudenschild, Dominik R.