Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.
Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.
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冷激活的棕色脂肪组织是女性较高骨矿物质密度的独立预测指标。
DOI：
10.1007/s00198-012-2110-y
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Celi FS
中科院分区：
文献类型：
--
作者：
Lee P;Brychta RJ;Collins MT;Linderman J;Smith S;Herscovitch P;Millo C;Chen KY;Celi FS
在动物中，棕色脂肪生成缺陷会导致骨质丢失。棕色脂肪组织(BAT)的质量是否与人类的骨密度(BMD)有关尚不清楚。我们采用冷刺激正电子发射断层扫描(PET)和双能X射线骨密度仪(DXA)测定了健康志愿者BAT质量与BMD的关系。与年龄和身体成分无关，健康女性的BAT质量越高，BMD越高，而男性的BMD与BMD无关。与传统的认为蝙蝠只存在于婴儿中的观点相反，最近的研究表明，蝙蝠在成年人中存在大量的储藏库。在动物中，棕色脂肪生成缺陷会导致骨质丢失。虽然白色脂肪组织质量是人类BMD的已知决定因素，但BAT和人类BMD之间的关系尚不清楚。因此，我们研究了健康成年人的BAT和BMD之间的关系。18F-脱氧葡萄糖(18F-FDG)正电子发射断层扫描(18F-FDG)测定BAT体积(Ml)和活性(标准摄取值(SUV))。24例健康成人(年龄28±1岁，女性=10)，BAT容量女性为82.4±99.5，男性为49.7±54.5毫升。女性BAT活性显著高于男性，为9.4±8.1%(p=0.03)。在女性中，蝙蝠体积与总骨密度和脊柱骨密度呈正相关(R2分别为0.40和0.49，p<；0.02)，在调整了年龄、脂肪和瘦体重后，BAT体积仍然是一个显著的预测因素(p<；0.05)。在PET图像上有肉眼可检测到BAT的女性的总BMD和脊柱BMD分别比没有BAT的女性高11±2%(p=0.02)和22±2%(p<；0.01)。未观察到男性BAT参数与BMD之间的关联。这项研究表明，BAT更丰富的健康女性的BMD更高，与年龄和其他身体成分参数无关。这在男性身上没有观察到。这些数据表明，棕色脂肪的形成可能与骨密度的调节有关。
In animals, defective brown adipogenesis leads to bone loss. Whether brown adipose tissue (BAT) mass relates to bone mineral density (BMD) in humans is unclear. We determined the relationship between BAT mass and BMD using cold-stimulated Positron Emission Tomography (PET) and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Higher BAT mass was associated with higher BMD in healthy women, but not men, independent of age and body composition. Contrary to traditional belief that BAT is present only in infants, recent studies revealed significant depots of BAT present in adult humans. In animals, defective brown adipogenesis leads to bone loss. While white adipose tissue mass is a known determinant of BMD in humans, the relationship between BAT and BMD in humans is unclear. We thus examined the relationship between BAT and BMD in healthy adults. BAT volume (ml) and activity (standard uptake value (SUV)) were determined by 18F-Fluorodeoxyglugose (18F-FDG) Positron Emission Tomography (PET) after overnight mild cold exposure at 19°C and BMD by DXA. Among 24 healthy adults (age 28±1 yr, F=10), BAT volumes were 82.4±99.5 in women and 49.7±54.5 ml in men. Women manifested significantly higher BAT activity, by 9.4±8.1% (p=0.03), than in men. BAT volume correlated positively with total and spine BMD (r2=0.40 and 0.49, respectively, p<0.02) in women and remained a significant predictor after adjustment for age, fat and lean body mass (p<0.05). Total and spine BMD was higher in women who harbored visually detectable BAT on PET images than those without by 11±2% (p=0.02) and 22±2% (p<0.01), respectively. No associations were observed between BAT parameters and BMD in men. This study demonstrated higher BMD among healthy women with more abundant BAT, independent of age and other body compositional parameters. This was not observed in men. The data suggest that brown adipogenesis may be physiologically related to modulation of bone density.
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影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
影响因子：
4.1
作者：
Krings, A.;Rahman, S.;Huang, S.;Lu, Y.;Czernik, P. J.;Lecka-Czernik, B.
通讯作者：
Lecka-Czernik, B.
DOI：
10.1152/ajpregu.00764.2010
发表时间：
2011-05-01
影响因子：
2.8
作者：
Motyl, Katherine J.;Raetz, Michelle;McCabe, Laura R.
通讯作者：
McCabe, Laura R.
影响因子：
5.8
作者：
Russell, Melissa;Mendes, Nara;Misra, Madhusmita
通讯作者：
Misra, Madhusmita
影响因子：
5.8
作者：
Janicka, Agnieszka;Wren, Tishya A. L.;Gilsanz, Vicente
通讯作者：
Gilsanz, Vicente