Acute exercise induces FGF21 expression in mice and in healthy humans.
Acute exercise induces FGF21 expression in mice and in healthy humans.
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DOI：
10.1371/journal.pone.0063517
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee MS
中科院分区：
文献类型：
--
作者：
Kim KH;Kim SH;Min YK;Yang HM;Lee JB;Lee MS
成纤维细胞生长因子21(FGF21)在饥饿时能量稳态的调节中起着重要作用，在治疗啮齿动物和猴子的2型糖尿病方面具有很好的治疗潜力。急性运动通过增加葡萄糖摄取和脂肪分解来影响葡萄糖和脂肪代谢。然而，目前尚不清楚急性运动是否会影响FGF21的表达。在这里，我们表明，在一次急性运动后，小鼠血清FGF21水平升高，并伴随着血清游离脂肪酸、甘油和酮体水平的增加。急性运动后，FGF21基因在小鼠肝脏中表达增加，但在骨骼肌和白色脂肪组织中未见表达，肝脏过氧化体增殖物激活受体α(PPARα)和激活转录因子4(ATF4)的基因表达水平也升高。此外，我们观察到健康男性志愿者在50%或80%最大摄氧量下进行跑步机跑步时，血清FGF21水平升高。这些结果表明，除了儿茶酚胺增加和胰岛素减少外，FGF21还可能与运动诱导的脂解有关。
Fibroblast growth factor 21 (FGF21) plays an important role in the regulation of energy homeostasis during starvation and has an excellent therapeutic potential for the treatment of type 2 diabetes in rodents and monkeys. Acute exercise affects glucose and lipid metabolism by increasing glucose uptake and lipolysis. However, it is not known whether acute exercise affects FGF21 expression. Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body. FGF21 gene expression was induced in the liver but not in skeletal muscle and white adipose tissue of mice after acute exercise, and further, the gene expression levels of hepatic peroxisome proliferator-activated receptor α (PPARα) and activating transcription factor 4 (ATF4) were also increased. In addition, we observed increased FGF21 level in serum of healthy male volunteers performing a treadmill run at 50 or 80% VO2max. These results suggest that FGF21 may also be associated with exercise-induced lipolysis in addition to increased catecholamines and reduced insulin.
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影响因子：
7.7
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