Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.
Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.
复制标题
C 型钠尿肽 (NTproCNP) 的氨基末端前肽可预测健康儿童的身高速度。
DOI：
10.1111/j.1365-2265.2012.04392.x
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发表时间：
2012-09
影响因子：
3.2
通讯作者：
Espiner EA
中科院分区：
文献类型：
--
作者：
Olney RC;Permuy JW;Prickett TC;Han JC;Espiner EA
C型利钠肽（CNP）是生长板的旁分泌调节因子，在软骨内生长中起关键作用。其氨基末端前肽（NTproCNP）是CNP生物合成的等摩尔产物，易于在血浆中测定。初步研究表明，NTproCNP水平与绵羊和儿童的身高增长速度相关。本研究的目的是将NTproCNP水平与身高增长速度相关联，并定义整个儿童期血浆CNP和NTproCNP的参考范围。这是一项针对健康儿童的前瞻性、横断面、观察性研究。参与者是258名2个月至20岁的健康儿童。获得人体测量数据，并通过放射免疫测定法测定CNP和NTproCNP水平。对于两种性别，CNP和NTproCNP水平在婴儿期较高，在幼儿期较低，在青春期升高，然后降至较低的成人水平。NTproCNP水平在男孩和女孩中分别在14.1岁和11.9岁时达到峰值，与身高增长速度峰值的年龄一致。NTproCNP的水平随青春期状态而变化，在男孩中在生殖器坦纳阶段IV达到峰值，在女孩中在生殖器阶段III达到峰值。NTproCNP与身高增长速度之间存在高度显著相关性。C型利钠肽在软骨内生长中起着不可或缺的作用。我们在此表明，CNP合成（通过血浆中的NTproCNP水平测量）与所有年龄的健康儿童的线性生长密切相关。我们提出NTproCNP作为线性生长的生物标志物。
C-type natriuretic peptide (CNP) is a paracrine regulatory factor of the growth plate and plays a key role in endochondral growth. Its amino-terminal propeptide (NTproCNP) is an equimolar product of CNP biosynthesis and is easily measured in plasma. Preliminary studies suggest that NTproCNP levels correlate with height velocity in sheep and children. The objectives of the study were to correlate NTproCNP levels with height velocity and to define the reference range for plasma CNP and NTproCNP across childhood. This was a prospective, cross-sectional, observational study of healthy children. Participants were 258 healthy children between 2 months and 20 years of age. Anthropometrics were obtained and CNP and NTproCNP levels were determined by radioimmunoassay. For both sexes, CNP and NTproCNP levels were high in infancy, lower in early childhood, rising during puberty, then falling to low adult levels. Levels of NTproCNP peaked at 14.1 years in boys and 11.9 years in girls, coincident with the age of peak height velocity. Levels of NTproCNP varied with pubertal status, peaking at genital Tanner stage IV in boys and III in girls. There was a highly significant correlation between NTproCNP and height velocity. C-type natriuretic peptide plays an integral role in endochondral growth. We show here that CNP synthesis (as measured by NTproCNP levels in plasma) is closely related to linear growth in healthy children at all ages. We propose NTproCNP as a biomarker of linear growth.
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影响因子：
3.3
作者：
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通讯作者：
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