Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers.
Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers.
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DOI：
10.1093/alcalc/agac047
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发表时间：
2023-01-09
影响因子：
2.8
通讯作者：
Joseph, Paule, V
中科院分区：
文献类型：
--
作者：
Agarwal, Khushbu;Luk, Jeremy W.;Manza, Peter;McDuffie, Christian;To, Leann;Jaime-Lara, Rosario B.;Stangl, Bethany L.;Schwandt, Melanie L.;Momenan, Reza;Goldman, David;Diazgranados, Nancy;Ramchandani, Vijay A.;Joseph, Paule, V
与大量饮酒相关的化学感觉功能障碍尚未得到充分研究，早期检测可以帮助预测与疾病相关的合并症，特别是与四个生活质量（QOL）领域（身体、心理、社会和环境）相关的合并症。我们研究了具有不同饮酒行为的个体的化学感觉能力的自我报告及其与生活质量领域变化的关系。参与者（n = 466）于2020年6月至2021年9月期间被招募到NIAAA COVID-19大流行对酒精的影响研究中。使用基于组的轨迹模型将没有任何已知COVID-19感染的参与者根据他们在四个不同时间点（入组时，第4周，第8周和第12周）的酒精使用障碍识别测试消费评分分为三组（非饮酒者，适度饮酒者和重度饮酒者）。线性混合模型用于检查这些组之间的化学感觉差异。在每组中确定化学感觉能力和QOL之间的关联。我们观察到严重饮酒者与非饮酒者相比，自我报告的嗅觉能力明显受损。相反，味觉能力在这些组之间表现出轻微的损害。适度饮酒组和不饮酒组的嗅觉和味觉能力没有显著差异。重度饮酒者的嗅觉和味觉能力受损与其生理、心理、社会和环境生活质量的恶化显著相关。持续大量饮酒与较低的化学感受能力有关。重度饮酒者的嗅觉和味觉功能降低，与较差的QOL相关，表明早期评估化学感觉变化可能对确定重度饮酒者酒精使用障碍风险的不良健康结果至关重要。 简短总结：持续大量饮酒导致嗅觉功能障碍，这在我们的纵向四个时间点研究中很明显。440名参与者的AUDIT消费评分的基于组的轨迹建模确定了重度，中度和非饮酒组。重度饮酒者（与非饮酒者相比）自我报告的嗅觉障碍显著，这与他们整体生活质量的恶化呈正相关。
Heavy alcohol consumption-associated chemosensory dysfunction is understudied, and early detection can help predict disease-associated comorbidities, especially those related to four quality of life (QOL) domains (physical, psychological, social and environment). We examined self-reports of chemosensory ability of individuals with different alcohol drinking behaviors and their association with changes in QOL domains. Participants (n = 466) were recruited between June 2020 and September 2021 into the NIAAA COVID-19 Pandemic Impact on Alcohol study. Group-based trajectory modeling was used to categorize participants without any known COVID-19 infection into three groups (non-drinkers, moderate drinkers and heavy drinkers) based on their Alcohol Use Disorders Identification Test consumption scores at four different time points (at enrollment, week 4, week 8 and week 12). Linear mixed models were used to examine chemosensory differences between these groups. The associations between chemosensory abilities and QOL were determined in each group. We observed significant impairment in self-reported smell ability of heavy drinking individuals compared to non-drinkers. In contrast, taste ability showed marginal impairment between these groups. There were no significant differences in smell and taste abilities between the moderate and non-drinking groups. Heavy drinkers’ impairment in smell and taste abilities was significantly associated with deterioration in their physical, psychological, social and environmental QOL. Persistent heavy drinking was associated with lower chemosensory ability. Heavy drinkers’ reduced smell and taste function and association with poorer QOL indicate that early assessment of chemosensory changes may be crucial in identifying poorer well-being outcomes in heavy drinkers at risk for alcohol use disorder. Short Summary: Persistent heavy alcohol drinking leads to smell dysfunction as evident from our longitudinal four time point study. Group-Based Trajectory Modeling on the AUDIT consumption scores of four hundred and forty participants identified heavy-, moderate-, and non-drinking groups. A significant self-reported smell impairment was seen in heavy drinkers (vs. non-drinkers), which associated positively with the deterioration in their overall quality of life.
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影响因子：
4.5
作者：
Bratberg GH;C Wilsnack S;Wilsnack R;Håvås Haugland S;Krokstad S;Sund ER;Bjørngaard JH
通讯作者：
Bjørngaard JH
DOI：
10.1007/s00406-007-0752-0
发表时间：
2007-10-01
影响因子：
4.7
作者：
Almeida-Filho, Naomar;Lessa, Ines;de Jesus Mari, Estela Aquino Jair
通讯作者：
de Jesus Mari, Estela Aquino Jair
影响因子：
3.8
作者：
Maurage P;Rombaux P;de Timary P
通讯作者：
de Timary P
影响因子：
16.4
作者：
Luk, Jeremy W.;Stangl, Bethany L.;Ramchandani, Vijay A.
通讯作者：
Ramchandani, Vijay A.
影响因子：
4.6
作者：
Cecchetto C;Di Pizio A;Genovese F;Calcinoni O;Macchi A;Dunkel A;Ohla K;Spinelli S;Farruggia MC;Joseph PV;Menini A;Cantone E;Dinnella C;Cecchini MP;D'Errico A;Mucignat-Caretta C;Parma V;Dibattista M
通讯作者：
Dibattista M