Olfaction in alcohol-dependence: a neglected yet promising research field.
Olfaction in alcohol-dependence: a neglected yet promising research field.
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DOI：
10.3389/fpsyg.2013.01007
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发表时间：
2013
影响因子：
3.8
通讯作者：
de Timary P
中科院分区：
文献类型：
--
作者：
Maurage P;Rombaux P;de Timary P
嗅觉研究深入更新了对各种精神病理状态的病理生理机制的认识，并表明嗅觉缺陷可能构成精神病学的发病或特征标记。然而，虽然酒精依赖是最广泛的精神疾病，而嗅觉可能参与其发展和维护，嗅觉能力在这一人群中很少被探索。因此，本文的中心目的是强调嗅觉研究在酒精依赖中的作用。在回顾了现有的几项嗅觉研究之后，提出了一个研究议程，确定了未来研究的主要挑战，特别是：（1）识别嗅觉缺陷的起源、程度和大脑相关性;（2）嗅觉和情感认知缺陷之间的联系，以及利用嗅觉理解酒精依赖的病理机制;（3）嗅觉与其他感觉方式之间的相互作用;（4）嗅觉对认知障碍的表现和程度的预测;（5）嗅觉缺陷对酒精依赖患者日常生活的影响。
Olfaction research deeply renewed the knowledge of the pathophysiological mechanisms involved in various psychopathological states and showed that olfactory deficits might constitute an onset or trait marker in psychiatry. However, while alcohol-dependence is the most wide spread psychiatric disorder and while olfaction might be involved in its development and maintenance, olfactory abilities have been little explored in this population. The central aim of this paper is thus to underline the usefulness of olfaction research in alcohol-dependence. After reviewing the few olfaction studies available, a research agenda will be proposed, identifying the major challenges for future research, and particularly: (1) the identification of the origin, extent and cerebral correlates of olfaction deficits; (2) the links between olfaction and emotional-cognitive deficits, and the use of olfaction to understand the pathomechanisms of alcohol-dependence; (3) the interactions between olfaction and other sensory modalities; (4) the use of olfaction to predict the appearance and intensity of cognitive impairments; (5) the impact of olfaction deficits on everyday life in alcohol-dependence.
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