Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study.
Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study.
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DOI：
10.2337/dc08-0026
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发表时间：
2008-07
期刊：
影响因子：
16.2
通讯作者：
Desvarieux M
中科院分区：
文献类型：
--
作者：
Demmer RT;Jacobs DR Jr;Desvarieux M
目的：2型糖尿病和牙周病已知是相关的，但这种关系的时代性尚未确定。在20年的随访中，我们调查了牙周病基线是否能独立预测糖尿病的发生。研究设计和方法：研究了9296名25-74岁的非糖尿病男性和女性国家健康与营养调查（NHANES I）参与者，他们完成了基线牙科检查（1971-1976），并至少进行了一次随访评估（1982-1992）。我们使用牙周指数定义了六类基线牙周病。在7168名有牙齿的参与者中，47%的人牙周指数为0（牙周健康）；其余按牙周指数五分位数进行分类。偶发性糖尿病的定义是：1)死亡证明（ICD-9代码250），2)需要药物治疗的糖尿病自我报告，或3)具有糖尿病出院代码的医疗机构住院日。多变量logistic回归模型评估了与牙周健康的参与者相比，牙周指数增加的参与者患糖尿病的几率。结果：牙周指数类别1和类别2患者发生糖尿病的调整优势比（or）未升高，而牙周指数类别3至类别5患者的调整优势比分别为2.26 （95% CI 1.56-3.27）、1.71 （95% CI 1.0-2.69）和1.50（0.99-2.27）。无牙受试者的OR为1.30（1.00-1.70）。牙齿严重脱落的参与者与牙齿轻微脱落的参与者相比，OR为1.70 （P < 0.05）。结论：在NHANES I的全国代表性样本中，基线牙周病是糖尿病发生的独立预测因子。
OBJECTIVE—Type 2 diabetes and periodontal disease are known to be associated, but the temporality of this relationship has not been firmly established. We investigated whether baseline periodontal disease independently predicts incident diabetes over two decades of follow-up. RESEARCH DESIGN AND METHODS—A total of 9,296 nondiabetic male and female National Health and Nutrition Examination Survey (NHANES I) participants aged 25–74 years who completed a baseline dental examination (1971–1976) and had at least one follow-up evaluation (1982–1992) were studied. We defined six categories of baseline periodontal disease using the periodontal index. Of 7,168 dentate participants, 47% had periodontal index = 0 (periodontally healthy); the remaining were classified into periodontal index quintiles. Incident diabetes was defined by 1) death certificate (ICD-9 code 250), 2) self-report of diabetes requiring pharmacological treatment, or 3) health care facility stay with diabetes discharge code. Multivariable logistic regression models assessed incident diabetes odds across increasing levels of periodontal index in comparison with periodontally healthy participants. RESULTS—The adjusted odds ratios (ORs) for incident diabetes in periodontal index categories 1 and 2 were not elevated, whereas the ORs in periodontal index categories 3 through 5 were 2.26 (95% CI 1.56–3.27), 1.71 (1.0–2.69), and 1.50 (0.99–2.27), respectively. The OR in edentulous participants was 1.30 (1.00–1.70). Dentate participants with advanced tooth loss had an OR of 1.70 (P < 0.05) relative to those with minimal tooth loss. CONCLUSIONS—Baseline periodontal disease is an independent predictor of incident diabetes in the nationally representative sample of NHANES I.
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影响因子：
5.3
作者：
Beck, JD;Eke, P;Offenbacher, S
通讯作者：
Offenbacher, S
影响因子：
37.8
作者：
Desvarieux, M;Demmer, RT;Papapanou, PN
通讯作者：
Papapanou, PN
影响因子：
8.3
作者：
Desvarieux, M;Demmer, RT;Sacco, RL
通讯作者：
Sacco, RL
影响因子：
6.7
作者：
Papapanou, Panos N.;Sedaghatfar, Michael H.;Pavlidis, Paul
通讯作者：
Pavlidis, Paul
DOI：
10.1902/annals.2002.7.1.79
发表时间：
2002-12-01
期刊：
Annals of periodontology
影响因子：
--
作者：
Beck, James D;Offenbacher, Steven
通讯作者：
Offenbacher, Steven