Mechanics and spiral formation in the rat cornea.
Mechanics and spiral formation in the rat cornea.
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DOI：
10.1007/s10237-014-0592-6
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发表时间：
2015-01
影响因子：
3.5
通讯作者：
Foster, C. D.
中科院分区：
文献类型：
--
作者：
Nejad, T. Mohammad;Iannaccone, S.;Rutherford, W.;Iannaccone, P. M.;Foster, C. D.
在一些哺乳动物（如小鼠和大鼠）的成熟过程中，角膜上皮细胞往往会随着时间的推移发育成螺旋状。更好地了解这些模式可以帮助了解器官如何发育，并可能深入了解影响角膜发育的一些疾病。在本文中，提出了一个框架来解释发展的上皮细胞形成螺旋图案由于拉伸和剪切应变的影响。使用嵌合动物，通过结合胚胎细胞从遗传上可区分的菌株，我们可以观察角膜图案的发展。随着器官和组织的发育，来自一个品系或另一个品系的细胞后代的聚集体形成，称为斑块。这些补丁的边界拟合对数螺旋共焦图像的成年大鼠角膜。为了与观察到的模式进行比较，我们开发了一个三维大应变有限元模型的大鼠角膜眼压下检查角膜表面上的应变分布。该模型包括整个角膜和一个几乎不可压缩的矩阵定向和分散的原纤维家庭的影响。跟踪角膜表面上的临界应变矢量的方向导致与所观察到的对数螺旋相比的螺旋状曲线。观察到的曲线和数值曲线之间的良好协议支持所提出的假设，即剪切和拉伸应变有利于滑动的上皮细胞发展螺旋图案。
During the maturation of some mammals such as mice and rats, corneal epithelial cells tend to develop into patterns such as spirals over time. A better understanding of these patterns can help to understand how the organ develops and may give insight into some of the diseases affecting corneal development. In this paper, a framework for explaining the development of the epithelial cells forming spiral patterns due to the effect of tensile and shear strains is proposed. Using chimeric animals, made by combining embryonic cells from genetically distinguishable strains, we can observe the development of patterns in the cornea. Aggregates of cell progeny from one strain or the other called patches form as organs and tissue develop. The boundaries of these patches are fitted with logarithmic spirals on confocal images of adult rat corneas. To compare with observed patterns, we develop a three-dimensional large strain finite element model for the rat cornea under intraocular pressure to examine the strain distribution on the cornea surface. The model includes the effects of oriented and dispersed fibrils families throughout the cornea and a nearly incompressible matrix. Tracing the directions of critical strain vectors on the cornea surface leads to spiral-like curves that are compared to the observed logarithmic spirals. Good agreement between the observed and numerical curves supports the proposed assumption that shear and tensile strains facilitate sliding of epithelial cells to develop spiral patterns.
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影响因子：
1
作者：
Carvalho, Luis Alberto;Prado, Marcelo;Chamon, Wallace
通讯作者：
Chamon, Wallace
影响因子：
5.7
作者：
Aghamohammadzadeh, H;Newton, RH;Meek, KM
通讯作者：
Meek, KM
影响因子：
4.4
作者：
Dvorscak, Lauren;Marfurt, Carl F.
通讯作者：
Marfurt, Carl F.
DOI：
10.1002/nme.2577
发表时间：
2009-07-23
影响因子：
2.9
作者：
Alastrue, V.;Martinez, M. A.;Doblare, M.
通讯作者：
Doblare, M.
影响因子：
4.8
作者：
Landini, G;Iannaccone, PM
通讯作者：
Iannaccone, PM