Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action.
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action.
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DOI：
10.1080/21505594.2017.1313372
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发表时间：
2018-01-01
期刊：
影响因子：
5.2
通讯作者：
Tiwari V
中科院分区：
文献类型：
--
作者：
Roy R;Tiwari M;Donelli G;Tiwari V
生物膜是指附着在表面或作为聚集体牢固地埋藏在细胞外基质中的复杂的、固着的微生物群落。细菌周围的生物膜基质使它们能够耐受恶劣的条件并抵抗抗菌治疗。此外，生物膜是导致广泛的慢性疾病的原因，并且由于细菌中抗生素耐药性的出现，实际上很难有效地治疗它们。此外，迄今为止可用的抗生素对于治疗这些生物膜相关感染是无效的，这是由于它们的最小抑制浓度（MIC）和最小杀菌浓度（MBC）的较高值，这可能导致体内毒性。因此，设计或筛选可以有效地最小化和根除生物膜相关感染的抗生物膜分子至关重要。在本文中，我们强调了生物膜形成的机制，参考不同的模型和用于生物膜检测的各种方法。迄今为止，人们的主要关注点是发现或测试的各种抗生物膜分子，其中可能包括草药活性化合物、螯合剂、肽抗生素、羊毛硫抗生素和合成化合物，沿着它们的结构、作用机制及其各自的MIC、MBC、最小生物膜抑制浓度（MBIC）以及半数最大抑制浓度（IC50）目前文献中的价值观。抗生物膜分子的不同作用模式是通过干扰群体感应途径、粘附机制、破坏细胞外DNA、蛋白质、脂多糖、胞外多糖和参与各种信号传导途径的第二信使来抑制。从这项研究中，我们得出结论，这里考虑的分子可能会被用来治疗生物膜相关的感染后，显着的结构修改，从而调查其在宿主中的有效传递。还应确保这些分子的最小有效浓度必须能够以最大效力根除生物膜感染，而不会对宿主造成任何不利的副作用。
Biofilm refers to the complex, sessile communities of microbes found either attached to a surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix surrounding bacteria makes them tolerant to harsh conditions and resistant to antibacterial treatments. Moreover, the biofilms are responsible for causing a broad range of chronic diseases and due to the emergence of antibiotic resistance in bacteria it has really become difficult to treat them with efficacy. Furthermore, the antibiotics available till date are ineffective for treating these biofilm related infections due to their higher values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), which may result in in-vivo toxicity. Hence, it is critically important to design or screen anti-biofilm molecules that can effectively minimize and eradicate biofilm related infections. In the present article, we have highlighted the mechanism of biofilm formation with reference to different models and various methods used for biofilm detection. A major focus has been put on various anti-biofilm molecules discovered or tested till date which may include herbal active compounds, chelating agents, peptide antibiotics, lantibiotics and synthetic chemical compounds along with their structures, mechanism of action and their respective MICs, MBCs, minimum biofilm inhibitory concentrations (MBICs) as well as the half maximal inhibitory concentration (IC50) values available in the literature so far. Different mode of action of anti biofilm molecules addressed here are inhibition via interference in the quorum sensing pathways, adhesion mechanism, disruption of extracellular DNA, protein, lipopolysaccharides, exopolysaccharides and secondary messengers involved in various signaling pathways. From this study, we conclude that the molecules considered here might be used to treat biofilm-associated infections after significant structural modifications, thereby investigating its effective delivery in the host. It should also be ensured that minimum effective concentration of these molecules must be capable of eradicating biofilm infections with maximum potency without posing any adverse side effects on the host.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
DOI：
10.3390/pathogens3020404
发表时间：
2014-05-06
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Amalaradjou MA;Venkitanarayanan K
通讯作者：
Venkitanarayanan K
影响因子：
4.6
作者：
Adil, Mohd;Singh, Kunal;Khan, Asad U.
通讯作者：
Khan, Asad U.
影响因子：
3.4
作者：
Baccile, Niki;Pedersen, Jan Skov;Van Bogaert, Inge N. A.
通讯作者：
Van Bogaert, Inge N. A.
影响因子：
2.9
作者：
Bhattacharjya, Surajit;Domadia, Prerna N.;David, Sunil A.
通讯作者：
David, Sunil A.