Sex, gender, and pain: an overview of a complex field.
Sex, gender, and pain: an overview of a complex field.
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DOI：
10.1213/01.ane.0b013e31816ba437
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发表时间：
2008-07
影响因子：
5.7
通讯作者：
Adams MC
中科院分区：
文献类型：
--
作者：
Hurley RW;Adams MC
传统上，疼痛领域的生物医学研究是用雄性动物和受试者进行的。在过去的20-30年里，人们越来越认识到，这种狭隘的方法忽略了一个重要的变量：性别。越来越多的研究已经确定了对疼痛和止痛药反应的性别差异。这些研究表明，两性之间的差异似乎有生物和心理基础。我们将简要回顾流行病学、啮齿动物和人类实验结果。文献中的争议和广泛分歧凸显了需要采取渐进的方法来解决涉及基础和临床生物医学科学培训人员与流行病学和社会科学培训人员之间合作努力的问题。为了使患有急性和/或慢性疼痛的患者从这项工作中受益，该方法必须涉及使用或开发临床相关的伤害感受或疼痛模型，以回答基本但复杂的问题。目前的文献状况不允许将这项工作转化为我们的临床决策。
Traditionally, biomedical research in the field of pain has been conducted with male animals and subjects. Over the past 20–30 yr, it has been increasingly recognized that this narrow approach has missed an important variable: sex. An ever-increasing number of studies have established sex differences in response to pain and analgesics. These studies have demonstrated that the differences between the sexes appear to have a biological and psychological basis. We will provide brief review of the epidemiology, rodent, and human experimental findings. The controversies and widespread disagreement in the literature highlight the need for a progressive approach to the questions involving collaborative efforts between those trained in the basic and clinical biomedical sciences and those in the epidemiological and social sciences. In order for patients suffering from acute and/or chronic pain to benefit from this work, the approach has to involve the use or development of clinically relevant models of nociception or pain to answer the basic, but complex, question. The present state of the literature allows no translation of the work to our clinical decision-making.
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