Neurocognitive correlates of alexithymia in asymptomatic individuals with HIV.
Neurocognitive correlates of alexithymia in asymptomatic individuals with HIV.
复制标题
无症状艾滋病毒感染者述情障碍的神经认知相关性。
DOI：
10.1016/j.neuropsychologia.2009.12.033
复制
发表时间：
2010-04
期刊：
影响因子：
2.6
通讯作者：
Cronin-Golomb A
中科院分区：
文献类型：
--
作者：
Bogdanova Y;Díaz-Santos M;Cronin-Golomb A
述情障碍是一种情感和认知情绪处理的障碍，通常与人类免疫缺陷病毒（HIV）有关，可能反映了病毒对大脑区域的影响，这些区域对多种认知功能也很重要，如前额叶和前扣带皮层。我们假设述情障碍的程度和与这些大脑区域相关的认知表现之间存在相关性，包括注意力、执行功能和视觉空间处理。34名无症状HIV阳性参与者和34名匹配的健康HIV阳性志愿者接受了多伦多述情障碍量表，一系列神经心理测试，以及冷漠、抑郁和生活质量（QoL）的测量。HIV阳性组的述情障碍、抑郁和冷漠程度明显高于HIV阴性组。述情障碍的程度及其两个处理成分（困难描述感觉[DDF]和外部导向思维），而不是抑郁，与执行能力和视觉空间能力的测量结果相关，与额纹状体回路及其皮层投射的功能障碍一致。冷漠与述情障碍和两个加工成分（情感识别困难和DDF）有关，但只与一项认知测量有关。在HIV中，述情障碍和认知功能障碍的高发率可能是额纹状体系统及其皮质连接受到感染的结果。我们的研究结果还证明了HIV中冷漠和述情障碍的分离，指出在额纹状体回路中重叠但不同的神经基质。述情障碍与生活质量评分密切相关，强调了评估和治疗hiv相关情绪和认知加工缺陷的重要性。
Alexithymia, an impairment of affective and cognitive emotional processing, is often associated with human immunodeficiency virus (HIV) and may reflect effects of the virus on brain areas that are also important for multiple cognitive functions, such as the prefrontal and anterior cingulate cortices. We hypothesized that there would be a correlation between extent of alexithymia and cognitive performance associated with these brain areas, including attention, executive function, and visuospatial processing. Thirty-four asymptomatic HIV+ participants and 34 matched healthy HIV− volunteers were administered the Toronto Alexithymia Scale, a series of neuropsychological tests, and measures of apathy, depression, and quality of life (QoL). The HIV+ participants had significantly higher levels of alexithymia, depression and apathy than the HIV− group. The extent of alexithymia and two of its processing components (Difficulty Describing Feelings [DDF] and Externally Oriented Thinking), but not depression, correlated with performance on measures of executive and visuospatial abilities, consistent with dysfunction of the frontostriatal circuits and their cortical projections. Apathy was related to alexithymia and two processing components (Difficulty Identifying Feelings and DDF) but to only one cognitive measure. The higher rate of alexithymia, as well as cognitive dysfunction, in HIV may be a consequence of the infection on the frontostriatal system and its cortical connections. Our findings also demonstrated a dissociation of apathy and alexithymia in HIV, pointing to overlapping but distinct neural substrates within frontostriatal circuits. Alexithymia correlated strongly with QoL ratings, underscoring the importance of assessment and treatment of HIV-associated emotional and cognitive processing deficits.
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DOI：
10.1007/s002590000351
发表时间：
2000-12-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Audenaert, K;Brans, B;Dierckx, R
通讯作者：
Dierckx, R
影响因子：
4.7
作者：
BAGBY, RM;PARKER, JDA;TAYLOR, GJ
通讯作者：
TAYLOR, GJ
影响因子：
25
作者：
Bishop, S;Duncan, J;Lawrence, AD
通讯作者：
Lawrence, AD
影响因子：
2.6
作者：
Bogdanova, Yelena;Neargarder, Sandy;Cronin-Golomb, Alice
通讯作者：
Cronin-Golomb, Alice
影响因子：
3.4
作者：
Bankier, B;Aigner, M;Bach, M
通讯作者：
Bach, M