Postnatal development of chorda tympani axons in the rat nucleus of the solitary tract.
Postnatal development of chorda tympani axons in the rat nucleus of the solitary tract.
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DOI：
10.1002/cne.23093
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发表时间：
2012-10-01
影响因子：
2.5
通讯作者：
Erisir, Alev
中科院分区：
文献类型：
--
作者：
Wang, Siting;Corson, James;Hill, David;Erisir, Alev
鼓索神经（CT）是向孤束核（NTS）传递味觉信息的三大神经之一，出生后第15天起，CT终末野发生重组。为了深入了解这一现象的机制，CT轴突投影场和终端形态在NTS分区进行了检查，使用道跟踪，光学显微镜和免疫电镜在四个出生后的年龄：P15，P25，P35，和成人。CT轴突支配的NTS rostrolateral细分在成人和P15大鼠的形态不同，从那些支配的rostrocentric，味觉细分。在这两个细分，CT终端P15前达到形态成熟。P15后，口外侧轴突（而非口中央轴突）经历了大量轴突分支消除。然而，在接下来的几周内，喙中央CT突触重新分布到突触后靶点上。对GABA能突触后靶点的CT末端偏好在P15后显著降低。此外，CT突触成为一个较小的组成部分，总的突触输入的口中央NTS后P35。结果强调，CT轴突在rostrocentral和rostrolateral分区代表两个不同的群体的CT输入，显示不同的形态学特性和结构重组机制在出生后的发展。
The chorda tympani nerve (CT), one of three nerves that convey gustatory information to nucleus of the solitary tract (NTS), displays terminal field reorganization after postnatal day 15 in the rat. Aiming to gain insight into mechanisms of this phenomenon, CT axon projection field and terminal morphology in NTS subdivisions were examined using tract tracing, light microscopy, and immuno-electron microscopy at four postnatal ages: P15, P25, P35, and adult. The CT axons that innervated NTS rostrolateral subdivision both in the adult and in P15 rats were morphologically distinct from those that innervated the rostrocentral, gustatory subdivision. In both subdivisions, CT terminals reached morphological maturity before P15. Rostrolateral, but not rostrocentral axons, went through substantial axonal branch elimination after P15. Rostrocentral CT synapses, however, redistribute onto postsynaptic targets in the following weeks. CT terminal preference for GABAergic postsynaptic targets was drastically reduced after P15. Furthermore, CT synapses became a smaller component of the total synaptic input to the rostrocentral NTS after P35. The results underlined that CT axons in rostrocentral and rostrolateral subdivisions represent two distinct populations of CT input, displaying different morphological properties and structural reorganization mechanisms during postnatal development.
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DOI：
10.1002/cne.22223
发表时间：
2010-03-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Bickford ME;Slusarczyk A;Dilger EK;Krahe TE;Kucuk C;Guido W
通讯作者：
Guido W
DOI：
10.1016/0165-3806(95)00020-e
发表时间：
1995-05-26
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
BAO, H;BRADLEY, RM;MISTRETTA, CM
通讯作者：
MISTRETTA, CM
影响因子：
16.2
作者：
Demas, J;Sagdullaev, BT;Guido, W
通讯作者：
Guido, W
影响因子：
2.5
作者：
BICKFORD, ME;GUNLUK, AE;SHERMAN, SM
通讯作者：
SHERMAN, SM
影响因子：
3.5
作者：
Harada, S;Yamamoto, T;Kasahara, Y
通讯作者：
Kasahara, Y