A comparison of temporal decay in place memory tasks in rats (Rattus norvegicus) with lesions affecting thalamus, frontal cortex, or the hippocampal system.

A comparison of temporal decay in place memory tasks in rats (Rattus norvegicus) with lesions affecting thalamus, frontal cortex, or the hippocampal system.
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大鼠(褐家鼠)位置记忆任务的时间衰退与影响丘脑、额叶皮层或海马系统损伤的比较。

DOI:
10.1037//0735-7044.110.6.1244
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发表时间:
1996
影响因子:
1.9
通讯作者:
Mair,RG
Mair,RG
中科院分区:
医学4区
文献类型:
--
作者:
Young,HL;Stevens,AA;Converse,E;Mair,RG

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三个实验比较了丘脑、皮层和海马系统的损伤区域对延迟匹配(DMTS)和不匹配(DNMTS)的影响。通过比较训练至稳定的大鼠在不同保留间隔(RI)的表现来测量时间衰减。病变的外侧内髓板网站在丘脑和内侧壁区额叶皮质产生的损害,显着大于病变的丘脑,穹窿,或背侧海马的背内侧核。病变对时间衰减的影响取决于如何操纵RI。当在训练期间操作RI时,DMTS和DNMTS损伤是延迟无关的(即,没有损伤增加时间衰减率)。当在会话之间操纵RI时,丘脑病变与DNMTS的时间衰减率增加相关。(PsycInfo数据库记录(c)2016阿帕,保留所有权利)
Three experiments compared the effects of lesioning areas of thalamus, cortex, and the hippocampal system on delayed matching (DMTS) and nonmatching (DNMTS) to sample. Temporal decay was measured by comparing performances at different retention intervals (RIs) for rats trained to stability. Lesions of the lateral-internal medullary lamina site in thalamus and the medial wall area in frontal cortex produced impairments that were significantly greater than for lesions of the mediodorsal nucleus in thalamus, the fornix, or the dorsal hippocampus. The effects of lesions on temporal decay differed depending on how RIs were manipulated. When RIs were manipulated within training sessions, the DMTS and DNMTS impairments were delay independent (ie, none of the lesions increased the rate of temporal decay). When RIs were manipulated between sessions, thalamic lesions were associated with an increase in the rate of temporal decay of DNMTS.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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