Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings.
Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings.
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DOI：
10.1021/acsami.1c01389
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发表时间：
2021-05-12
影响因子：
9.5
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Ghimire A;Song J
尽管有先进的植入物消毒和无菌外科技术，但假体周围细菌感染仍然是骨科和牙科植入物的主要挑战。种植体周围细菌定植/生物膜的形成及其对致密骨组织基质的侵袭很难治疗，并可能导致种植体失败和骨髓炎。这些并发症需要进行重大的翻修手术和延长抗生素治疗，这与高昂的治疗成本、发病率甚至死亡率有关。因此，迫切需要采取有效的预防措施，降低与种植体相关的感染风险。本文综述了近年来抗假体周围感染的研究进展，旨在减少细菌黏附、定植和生物被膜的形成，或直接杀死与种植体接触和/或附近的细菌。这些目标是通过防污染、群体感应干扰或杀菌植入物表面形貌工程或通过化学修饰的表面涂层来实现的。介绍了模拟超疏水防污特性的荷叶表面形貌工程和仿蝉振翅、穿透细菌的纳米粒子。传统的物理包衣/被动释放杀菌剂与它们的共价连接不同，它们通过稳定的键或不能被细菌酶裂解或环境扰动的键连接到植入物表面。这些新出现的抗假体周围感染的方法的利弊从安全性、有效性和翻译潜力方面进行了讨论。
Despite advanced implant sterilization and aseptic surgical techniques, periprosthetic bacterial infection remains a major challenge for orthopedic and dental implants. Bacterial colonization/biofilm formation around implants and their invasion into the dense skeletal tissue matrices are difficult to treat and could lead to implant failure and osteomyelitis. These complications require major revision surgeries and extended antibiotic therapies that are associated with high treatment cost, morbidity and even mortality. Effective preventative measures mitigating risks for implant related infections are thus in dire need. This review focuses on recent developments of anti-periprosthetic infection strategies aimed at either reducing bacterial adhesion, colonization and biofilm formation or killing bacteria directly in contact with and/or in the vicinity of implants. These goals are accomplished through anti-fouling, quorum sensing-interfering or bactericidal implant surface topographical engineering or surface coatings through chemical modifications. Surface topographical engineering of lotus-leaf mimicking superhydrophobic anti-fouling features and cicada wing-mimicking, bacterium-piercing nanopillars are both presented. Conventional physical coating/passive release of bactericidal agents is contrasted with their covalent tethering to implant surfaces through either stable linkages or linkages labile to bacterial enzyme cleavage or environmental perturbations. Pros and cons of these emerging anti-periprosthetic infection approaches are discussed in terms of their safety, efficacy and translational potentials.
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影响因子：
3.3
作者：
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纳米结构的钛表面表现出对葡萄球菌生物膜形成的顽固性。
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