Regional variation in phasic dopamine release during alcohol and sucrose self-administration in rats.
Regional variation in phasic dopamine release during alcohol and sucrose self-administration in rats.
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DOI：
10.1021/cn500251j
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发表时间：
2015-01-21
影响因子：
5
通讯作者：
Robinson, Donita L.
中科院分区：
文献类型：
--
作者：
Shnitko, Tatiana A.;Robinson, Donita L.
虽然多巴胺输入背侧纹状体是众所周知的是至关重要的行动选择，包括酒精动机的行为，它是未知的，是否相多巴胺的变化伴随着这些行为。长期酗酒被认为会促进腹侧和背侧纹状体中奖励学习神经回路的改变，可能是通过增加多巴胺的释放。使用快速扫描循环伏安法，我们测量了阶段性多巴胺释放的背侧和腹侧纹状体在酒精和非酒精的奖励寻求行为和奖励相关的线索在大鼠训练的可变间隔时间表的强化。我们观察到强大的阶段性多巴胺释放后，加强杠杆压力和不一致的多巴胺释放背内侧纹状体的背外侧纹状体。与我们的预期相反，酒精并没有增强大鼠饮用酒精奖励的多巴胺释放。在饮用奖励溶液的大鼠的延髓核核心中也观察到线索诱导的多巴胺释放。这些数据表明，酒精和非酒精的奖励自我管理的可变间隔时间表的强化大鼠伴随着阶段性多巴胺释放时间锁定到加强在背外侧纹状体和背内侧纹状体，但不是背内侧纹状体。
While dopamine input to the dorsal striatum is well-known to be critical for action selection, including alcohol-motivated behaviors, it is unknown whether changes in phasic dopamine accompany these behaviors. Long-term alcohol abuse is believed to promote alterations in the neurocircuitry of reward learning in both ventral and dorsal striatum, potentially through increasing dopamine release. Using fast-scan cyclic voltammetry, we measured phasic dopamine release in the dorsal and ventral striatum during alcoholic and nonalcoholic reward-seeking behavior and reward-related cues in rats trained on a variable-interval schedule of reinforcement. We observed robust phasic dopamine release in the dorsolateral striatum after reinforced lever presses and inconsistent dopamine release in the dorsomedial striatum. Contrary to our expectations, alcohol did not enhance dopamine release in rats drinking alcoholic rewards. Cue-induced dopamine release was also observed in the nucleus accumbens core of rats drinking the reward solutions. These data demonstrate that alcoholic and nonalcoholic reward self-administration on a variable-interval schedule of reinforcement in rats is accompanied by phasic dopamine release time-locked to reinforcement in the dorsolateral striatum and the nucleus accumbens, but not the dorsomedial striatum.
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影响因子：
5
作者：
Keithley, Richard B.;Wightman, R. Mark
通讯作者：
Wightman, R. Mark
DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.6
作者：
Averbeck, Bruno B.;Crowe, David A.;Georgopoulos, Apostolos P.
通讯作者：
Georgopoulos, Apostolos P.
影响因子：
4.1
作者：
Da Cunha, Claudio;Gomez-A, Alexander;Blaha, Charles D.
通讯作者：
Blaha, Charles D.
寻求习惯性酒精：建模从休闲饮酒到成瘾的过渡。
影响因子：
8.2
作者：
Barker, Jacqueline M.;Taylor, Jane R.
通讯作者：
Taylor, Jane R.