Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner.
Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner.
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DOI：
10.1038/s41598-017-04659-9
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Douek P
中科院分区：
文献类型：
--
作者：
Cormode DP;Si-Mohamed S;Bar-Ness D;Sigovan M;Naha PC;Balegamire J;Lavenne F;Coulon P;Roessl E;Bartels M;Rokni M;Blevis I;Boussel L;Douek P
基于改进的临床 CT 系统的新型光谱光子计数计算机断层扫描 (SPCCT) 原型已经开发出来。对透射 X 射线光谱的能量成分进行 SPCCT 分析可能允许同时进行双造影剂成像，但是，这种系统尚未证实这一点。我们研究了使用该系统区分金纳米粒子 (AuNP) 和碘造影剂的可行性。造影剂和磷酸钙在体模中成像。生成了传统 CT、金 K 边缘、碘和水图像，并证明了对含有造影剂混合物的体模中金和碘浓度的准确辨别和量化。使用新西兰白兔在注射 AuNP 和碘造影剂后的几个时间点进行体内实验。我们发现造影剂图清楚地区分了组织中金和碘的分布，从而可以量化造影剂的浓度，这与其预期的药代动力学相匹配。此外，还进行了快速、重复的扫描，这使得能够以高时间分辨率测量造影剂动力学。总之，临床规模、高计数率的SPCCT系统能够区分体内不同器官中的金和碘造影剂。
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.
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影响因子：
5.9
作者：
Anderson, N. G.;Butler, A. P.;Butler, P. H.
通讯作者：
Butler, P. H.
影响因子：
17.1
作者：
Bonitatibus, Peter J., Jr.;Torres, Andrew S.;Marino, Michael E.
通讯作者：
Marino, Michael E.
影响因子：
--
作者：
Cormode, David P.;Naha, Pratap C.;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
DOI：
10.2967/jnumed.115.157982
发表时间：
2015-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Blasi F;Oliveira BL;Rietz TA;Rotile NJ;Day H;Naha PC;Cormode DP;Izquierdo-Garcia D;Catana C;Caravan P
通讯作者：
Caravan P
影响因子：
5.5
作者：
Agrawal, Mukta D.;Pinho, Daniella F.;Sahani, Dushyant V.
通讯作者：
Sahani, Dushyant V.