Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.
Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.
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DOI：
10.1093/braincomms/fcac031
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发表时间：
2022
影响因子：
4.8
通讯作者：
Houde J
中科院分区：
文献类型：
--
作者：
Kothare H;Schneider S;Mizuiri D;Hinkley L;Bhutada A;Ranasinghe K;Honma S;Garrett C;Klein D;Naunheim M;Yung K;Cheung S;Rosen C;Courey M;Nagarajan S;Houde J
喉肌张力障碍是一种使人衰弱的发声障碍，其中喉肌肉间歇性痉挛，导致说话过程中的不自主中断。喉肌张力障碍的中枢病理生理学，潜在的计算障碍，在声乐运动控制，仍然知之甚少。虽然先前的成像研究已经发现了异常活动的中枢神经系统在发声与喉肌张力障碍患者，它是不知道在什么时间点发声这些异常出现，什么功能可能会受损。为了研究这个问题，我们招募了22名喉内收肌张力障碍患者（15名女性，年龄范围= 28.83-72.46岁）和18名对照组（8名女性，年龄范围= 27.40-71.34岁）。我们利用脑磁图的精细时间分辨率来监测声门运动开始时、随后的语音开始时和音调反馈扰动开始后的神经活动。我们研究了事件相关的β-波段（12-30 Hz）和高γ-波段（65-150 Hz）神经振荡。 在声门运动开始之前，我们观察到异常的额顶叶运动准备活动。声门运动开始后，我们观察到异常活动的躯体感觉皮层持续通过语音发作。在发声之前和发声之后，我们还观察到听觉皮层和小脑的异常活动。在音高反馈扰动发作后，我们观察到控制组和患者对扰动的行为反应没有差异。但在患者中，我们确实发现了被认为与音高的听觉反馈控制有关的大脑区域（前运动皮层、运动皮层、体感皮层和听觉皮层）的异常活动。我们的研究结果证实了在其他研究中看到的躯体感觉反馈的异常处理。然而，在我们的研究中有几个显著的发现。首先，患者在声门运动开始之前就已经有发声运动活动受损，提示运动准备异常。这些结果是有意义的，因为（i）它们发生在运动开始之前，患者的异常不能归因于发声能力的缺陷，（ii）它们表明喉肌张力障碍的神经异常不仅仅是发声过程中对感觉反馈的异常反应，正如一些先前的研究所假设的那样。第二，患者的异常听觉皮层活动甚至在声音出现之前就开始了，这表明在声音出现时听觉反馈到达之前，听觉预测的建立是异常的。一般来说，激活异常的言语运动网络内的关键脑区周围的各种发声事件，不仅提供了时间特异性的神经影像学表现型喉肌张力障碍，但也可以作为潜在的治疗目标，神经调节。Kothare等人报告说，脑磁图成像能够对喉肌张力障碍（LD）中发声事件周围的异常神经活动进行功能推断。在这些事件周围的言语运动网络内识别的激活异常不仅为LD的神经影像学表型提供了时间特异性，而且还可以作为神经调节的治疗靶点。
Laryngeal dystonia is a debilitating disorder of voicing in which the laryngeal muscles are intermittently in spasm resulting in involuntary interruptions during speech. The central pathophysiology of laryngeal dystonia, underlying computational impairments in vocal motor control, remains poorly understood. Although prior imaging studies have found aberrant activity in the CNS during phonation in patients with laryngeal dystonia, it is not known at what timepoints during phonation these abnormalities emerge and what function may be impaired. To investigate this question, we recruited 22 adductor laryngeal dystonia patients (15 female, age range = 28.83–72.46 years) and 18 controls (eight female, age range = 27.40–71.34 years). We leveraged the fine temporal resolution of magnetoencephalography to monitor neural activity around glottal movement onset, subsequent voice onset and after the onset of pitch feedback perturbations. We examined event-related beta-band (12–30 Hz) and high-gamma-band (65–150 Hz) neural oscillations. Prior to glottal movement onset, we observed abnormal frontoparietal motor preparatory activity. After glottal movement onset, we observed abnormal activity in the somatosensory cortex persisting through voice onset. Prior to voice onset and continuing after, we also observed abnormal activity in the auditory cortex and the cerebellum. After pitch feedback perturbation onset, we observed no differences between controls and patients in their behavioural responses to the perturbation. But in patients, we did find abnormal activity in brain regions thought to be involved in the auditory feedback control of vocal pitch (premotor, motor, somatosensory and auditory cortices). Our study results confirm the abnormal processing of somatosensory feedback that has been seen in other studies. However, there were several remarkable findings in our study. First, patients have impaired vocal motor activity even before glottal movement onset, suggesting abnormal movement preparation. These results are significant because (i) they occur before movement onset, abnormalities in patients cannot be ascribed to deficits in vocal performance and (ii) they show that neural abnormalities in laryngeal dystonia are more than just abnormal responses to sensory feedback during phonation as has been hypothesized in some previous studies. Second, abnormal auditory cortical activity in patients begins even before voice onset, suggesting abnormalities in setting up auditory predictions before the arrival of auditory feedback at voice onset. Generally, activation abnormalities identified in key brain regions within the speech motor network around various phonation events not only provide temporal specificity to neuroimaging phenotypes in laryngeal dystonia but also may serve as potential therapeutic targets for neuromodulation. Kothare et al. report that magnetoencephalographic imaging enables functional inferences about abnormal neural activity around phonatory events in laryngeal dystonia (LD). Activation abnormalities identified within the speech motor network around these events not only provide temporal specificity to neuroimaging phenotypes in LD but also may serve as therapeutic targets for neuromodulation.
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影响因子：
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作者：
Dalal SS;Zumer JM;Guggisberg AG;Trumpis M;Wong DD;Sekihara K;Nagarajan SS
通讯作者：
Nagarajan SS
DOI：
10.1044/1092-4388(2006/081
发表时间：
2006-10-01
影响因子：
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DOI：
10.1044/1092-4388(2002/037
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2002-06-01
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2.6
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3.4
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Hinkley, Leighton B N;Dolberg, Rebecca;Nagarajan, Srikantan S
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Nagarajan, Srikantan S