C. elegans ageing is accelerated by a self-destructive reproductive programme.
C. elegans ageing is accelerated by a self-destructive reproductive programme.
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DOI：
10.1038/s41467-023-40088-1
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发表时间：
2023-07-20
影响因子：
16.6
通讯作者：
Gems, David
中科院分区：
文献类型：
--
作者：
Kern, Carina C.;Srivastava, Shivangi;Ezcurra, Marina;Hsiung, Kuei Ching;Hui, Nancy;Townsend, StJohn;Maczik, Dominik;Zhang, Bruce;Tse, Victoria;Konstantellos, Viktoras;Bahler, Juerg;Gems, David
生殖后C.在线虫中，破坏性的体细胞生物量再利用支持卵黄的产生，最近显示，卵黄被排出并且可以用作幼虫后代的食物。这让人想起了太平洋鲑鱼等单胎生物典型的自杀性生殖努力（生殖死亡）。探讨C. elegans的表现出生殖死亡，我们比较了兄弟种对属Caelihabditis和Pristionchus雌雄同体和女性。我们报告说，蛋黄排气和组成，早期病理学涉及主要的解剖变化只发生在雌雄同体，这也是较短的生活。此外，只有在雌雄同体中，生殖细胞的去除才能抑制衰老病理学并显着增加寿命。这与C.线虫表现出生殖死亡，生殖细胞消融抑制。如果正确的话，这将意味着C。elegans和大多数高等生物，并可能解释C. elegans老化秀丽隐杆线虫被用作研究衰老的模式物种，但在寿命方面具有非常高的可塑性。本研究认为，C。与许多其他生物不同，秀丽线虫是由自杀性生殖努力驱动的。
In post-reproductive C. elegans, destructive somatic biomass repurposing supports production of yolk which, it was recently shown, is vented and can serve as a foodstuff for larval progeny. This is reminiscent of the suicidal reproductive effort (reproductive death) typical of semelparous organisms such as Pacific salmon. To explore the possibility that C. elegans exhibits reproductive death, we have compared sibling species pairs of the genera Caenorhabditis and Pristionchus with hermaphrodites and females. We report that yolk venting and constitutive, early pathology involving major anatomical changes occur only in hermaphrodites, which are also shorter lived. Moreover, only in hermaphrodites does germline removal suppress senescent pathology and markedly increase lifespan. This is consistent with the hypothesis that C. elegans exhibit reproductive death that is suppressed by germline ablation. If correct, this would imply a major difference in the ageing process between C. elegans and most higher organisms, and potentially explain the exceptional plasticity in C. elegans ageing. Caenorhabditis elegans is used as a model species to investigate ageing, yet has a very high degree of plasticity in lifespan. This study argues that ageing in C. elegans is driven by suicidal reproductive effort, unlike many other organisms.
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