The Vehicle Determines the Destination: The Significance of Seminal Plasma Factors for Male Fertility.
The Vehicle Determines the Destination: The Significance of Seminal Plasma Factors for Male Fertility.
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车辆决定目的地：精浆因素对男性生育能力的意义
DOI：
10.3390/ijms21228499
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发表时间：
2020-11-12
影响因子：
5.6
通讯作者：
Yuan S
中科院分区：
文献类型：
--
作者：
Wang F;Yang W;Ouyang S;Yuan S
在所有人类不育病例中，高达 50% 的病例显示出导致男性生殖生理缺陷的因素。精浆（SP）是来自男性副性腺的生物液体，在射精时携带精子穿过男性和女性生殖道。它包含一组复杂的异质分子结构，包括蛋白质、无细胞核酸（DNA、microRNA 和 LncRNA）、小分子代谢物以及无机化学物质（离子）。长期以来，精浆因子功能的实质意义被低估，其作用仅限于精子的运输和保护。值得注意的是，近年来在精浆成分的解析方面取得了重大进展，揭示了对精子功能以及受精和妊娠结局多个方面的新见解。在这篇综述中，我们总结了有关 SP 成分及其对男性生育力的影响的最新发现，特别描述了使用“组学”方法对精浆成分和相关修饰的新理解，并主要关注近十年来的蛋白质组和 RNA-seq 数据。同时，我们重点介绍了SP分子对女性生殖道免疫调节的调节机制。此外，我们还讨论了在临床上作为男性不育症非侵入性诊断生物标志物进行研究的蛋白质。
Of all human infertility cases, up to 50% show contributing factors leading to defects in the male reproductive physiology. Seminal plasma (SP) is the biological fluid derived from the male accessory sex gland which carries spermatozoa passing throughout the male and female reproductive tract during ejaculation. It contains a complicated set of heterogeneous molecular structures, including proteins, cell-free nucleic acid (DNA, microRNA and LncRNA), and small-molecule metabolites as well as inorganic chemicals (ions). For a long time, the substantial significance of seminal plasma factors’ functions has been underestimated, which is restricted to spermatozoa transport and protection. Notably, significant advancements have been made in dissecting seminal plasma components, revealing new insights into multiple aspects of sperm function, as well as fertilization and pregnancy outcomes in recent years. In this review, we summarize the state-of-art discoveries regarding SP compositions and their implications in male fertility, particularly describing the novel understanding of seminal plasma components and related modifications using “omics” approaches and mainly focusing on proteome and RNA-seq data in the latest decade. Meanwhile, we highlighted the proposed mechanism of the regulation of SP molecules on immunomodulation in the female reproductive tract. Moreover, we also discussed the proteins investigated as non-invasive diagnosis biomarkers for male infertility in the clinic.
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影响因子：
11.1
作者：
Bonasio R;Shiekhattar R
通讯作者：
Shiekhattar R
影响因子：
4.1
作者：
Budnik, LT;Jähner, D;Mukhopadhyay, AK
通讯作者：
Mukhopadhyay, AK
DOI：
10.1016/j.ejogrb.2018.10.048
发表时间：
2018-12-01
影响因子：
2.6
作者：
Chen, Yuezhou;Liao, Tantan;Jin, Lei
通讯作者：
Jin, Lei
DOI：
10.1080/01485010390129232
发表时间：
2003-03-01
期刊：
ARCHIVES OF ANDROLOGY
影响因子：
--
作者：
Camejo, MI
通讯作者：
Camejo, MI
影响因子：
--
作者：
Cadavid J AP;Alvarez A;Markert UR;Cardona Maya W
通讯作者：
Cardona Maya W