Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage.
Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage.
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DOI：
10.1038/s41598-017-08624-4
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发表时间：
2017-08-14
影响因子：
4.6
通讯作者：
Nakazawa T
中科院分区：
文献类型：
--
作者：
Asano Y;Himori N;Kunikata H;Yamazaki M;Shiga Y;Omodaka K;Takahashi H;Nakazawa T
全身性氧化应激被认为是青光眼发病机制中的重要因素。特别是，通常对抗氧化应激的全身抗氧化能力低可能导致青光眼。因此，我们研究了生物抗氧化潜力（BAP），全身抗氧化能力的生物标志物，与开角型青光眼（OAG）患者的青光眼严重程度之间的关系。本研究包括240例OAG患者的480只眼和66例健康对照眼。我们用自由基分析仪测量BAP血清水平，并将其与视网膜神经节细胞（wrgc）数量的加权估计值进行比较，后者来自视乳头周围视网膜神经纤维层厚度和视野平均偏差。我们发现在所有的OAG患者中，男性和女性患者wrgc与BAP均不相关，但在年轻（年龄≤ 65岁）男性OAG患者中相关（较好的眼睛：r = 0.33，P = 0.02;较差的眼睛：r = 0.27，P = 0.047）。此外，混合效应回归分析显示，BAP是年轻男性OAG患者wrgc的独立影响因素（P = 0.02）。因此，在相对年轻的男性患者中，全身抗氧化能力与脑损伤相关，这表明抗氧化治疗可能对这些患者更有效。
Systemic oxidative stress is thought to be an important factor in the pathogenesis of glaucoma. In particular, low systemic antioxidative capacity, which normally counters oxidative stress, may contribute to glaucoma. Thus, we investigated the association between biological antioxidant potential (BAP), a biomarker of systemic antioxidative capacity, and glaucoma severity in patients with open-angle glaucoma (OAG). This study included 480 eyes of 240 patients with OAG and 66 healthy control eyes. We measured the BAP serum level with a free radical analyzer and compared it with a weighted estimate of the number of retinal ganglion cells (wrgc), derived from circumpapillary retinal nerve fiber layer thickness and visual field mean deviation. We found that wrgc was uncorrelated with BAP in the overall, male, and female OAG patients, but was correlated in young (aged ≤ 65 years) male OAG patients (better eye: r = 0.33, P = 0.02; worse eye: r = 0.27, P = 0.047). Furthermore, a mixed-effects regression analysis revealed that BAP was an independent contributing factor to wrgc in young male OAG patients (P = 0.02). Thus, systemic antioxidant capacity was associated with glaucomatous damage in relatively young male patients, suggesting that anti-oxidant therapy might be more effective in these patients.
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影响因子：
3.7
作者：
Aizawa N;Kunikata H;Nitta F;Shiga Y;Omodaka K;Tsuda S;Nakazawa T
通讯作者：
Nakazawa T
影响因子：
3.7
作者：
Tanito M;Kaidzu S;Takai Y;Ohira A
通讯作者：
Ohira A
影响因子：
4.8
作者：
Kitaoka, Yasushi;Munemasa, Yasunari;Ueno, Satoki
通讯作者：
Ueno, Satoki
影响因子：
5.3
作者：
Higashi, Yukihito;Sasaki, Shota;Yoshizumi, Masao
通讯作者：
Yoshizumi, Masao
影响因子：
7.4
作者：
Scott, Erin;Zhang, Quan-guang;Wang, Ruimin;Vadlamudi, Ratna;Brann, Darrell
通讯作者：
Brann, Darrell