Roles of ESCRT-III polymers in cell division across the tree of life.

Roles of ESCRT-III polymers in cell division across the tree of life.
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DOI:
10.1016/j.ceb.2023.102274
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发表时间:
2023-12
影响因子:
7.5
通讯作者:
Baum B
Baum B
中科院分区:
生物学2区
文献类型:
--
作者:
Carlton JG;Baum B

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每个细胞通过精心策划的分裂过程变成两个。在分裂之前,收缩机制必须首先在细胞中间区域组装,以确保切割时将遗传物质的两个分离的副本一分为二。其次,这种收缩机制必须动态地束缚在限制质膜上,以便在收缩时带动膜一起运动。最后,必须切断连接膜以产生两个物理上独立的子细胞。在生命之树的多种生物体中,运输所需的内体分选复合物 (ESCRT)-III 家族蛋白通过形成复合聚合物来帮助细胞分裂,该复合聚合物与 Vps4 AAA-ATP 酶一起发挥作用,从内部收缩和切割连接新生子细胞的膜管。在这篇综述中,我们讨论了 ESCRT-III 的独特特征,这些特征使其能够在许多古细菌和真核生物的分裂中发挥作用。
Every cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts. Finally, the connecting membrane must be severed to generate two physically separate daughter cells. In several organisms across the tree of life, Endosomal Sorting Complex Required for Transport (ESCRT)-III family proteins aid cell division by forming composite polymers that function together with the Vps4 AAA-ATPase to constrict and cut the membrane tube connecting nascent daughter cells from the inside. In this review, we discuss unique features of ESCRT-III that enable it to play this role in division in many archaea and eukaryotes.
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