Functions of astrocytes and their potential as therapeutic targets.
Functions of astrocytes and their potential as therapeutic targets.
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DOI：
10.1016/j.nurt.2010.07.006
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Nedergaard M
中科院分区：
文献类型：
--
作者：
Kimelberg HK;Nedergaard M
星形胶质细胞通常被认为是哺乳动物中枢神经系统的支持细胞，并且在历史上被认为是哺乳动物中枢神经系统的支持细胞。过去十年的工作表明，星形胶质细胞实际上可能在高级神经处理中发挥比以前认识到的更积极的作用。由于星形胶质细胞可能成为新的治疗靶点，因此了解星形胶质细胞如何在维持神经元健康的同时执行各种支持任务至关重要。为此，本次审查将集中在星形胶质细胞的支持作用，基本上所有的急性和慢性神经系统疾病相关的研究线。此外，这篇评论将严格重新评估我们的概念，星形胶质细胞的功能特性，并将这些任务与其复杂的形态。
Astrocytes are often referred to, and historically have been regarded as, support cells of the mammalian CNS. Work over the last decade suggests otherwise, that astrocytes may in fact play a more active role in higher neural processing than previously recognized. Because astrocytes can potentially serve as novel therapeutic targets, it is critical to understand how astrocytes execute their diverse supportive tasks while maintaining neuronal health. To that end, this review will focus on the supportive roles of astrocytes, a line of study relevant to essentially all acute and chronic neurological diseases. Furthermore, this review will critically re-evaluate our concepts of the functional properties of astrocytes and relate these tasks to their intricate morphology.
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