Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex.
Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex.
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腹侧被盖区激活通过初级听觉皮层的电路抑制来提高射击精度和强度
DOI：
10.3389/fncir.2014.00025
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发表时间：
2014
影响因子：
3.5
通讯作者：
Xiong Y
中科院分区：
文献类型：
--
作者：
Lou Y;Luo W;Zhang G;Tao C;Chen P;Zhou Y;Xiong Y
腹侧被盖区（VTA）的激活可以重建初级听觉皮层（A1）的张力表征，但其细胞机制仍不清楚。本研究采用体内细胞内记录的方法研究了VTA激活对A1神经元放电模式和膜电位动态的影响。我们发现VTA激活可以显著降低声音诱发反应的变异性，提高A1神经元的放电精度和强度。此外，压缩的响应窗口是由早期超极化引起的，这是电路抑制增强的结果。我们的研究提出了奖赏系统影响感觉皮层信息加工的可能机制：VTA激活增强了皮层抑制，缩短了突触后皮层神经元的反应窗口，进一步提高了神经元活动的精度和强度。
The activation of the ventral tegmental area (VTA) can rebuild the tonotopic representation in the primary auditory cortex (A1), but the cellular mechanisms remain largely unknown. Here, we investigated the firing patterns and membrane potential dynamics of neurons in A1 under the influence of VTA activation using in vivo intracellular recording. We found that VTA activation can significantly reduce the variability of sound evoked responses and promote the firing precision and strength of A1 neurons. Furthermore, the compressed response window was caused by an early hyperpolarization as a result of enhanced circuit inhibition. Our study suggested a possible mechanism of how the reward system affects information processing in sensory cortex: VTA activation strengthens cortical inhibition, which shortens the response window of post-synaptic cortical neurons and further promotes the precision and strength of neuronal activity.
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特定中间神经元的激活可提高 V1 特征选择性和视觉感知。
影响因子：
64.8
作者：
Lee, Seung-Hee;Kwan, Alex C.;Zhang, Siyu;Phoumthipphavong, Victoria;Flannery, John G.;Masmanidis, Sotiris C.;Taniguchi, Hiroki;Huang, Z. Josh;Zhang, Feng;Boyden, Edward S.;Deisseroth, Karl;Dan, Yang
通讯作者：
Dan, Yang
影响因子：
2.5
作者：
Favero, Morgana;Varghese, Gladis;Castro-Alamancos, Manuel A.
通讯作者：
Castro-Alamancos, Manuel A.
影响因子：
2
作者：
Kudoh, Masaharu;Shibuki, Katsuei
通讯作者：
Shibuki, Katsuei
影响因子：
2.5
作者：
Lee, Jong-Ju;Cho, Young-Wuk;Yeo, Seung Geun
通讯作者：
Yeo, Seung Geun
DOI：
10.1073/pnas.0503851102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Ma, XF;Suga, N
通讯作者：
Suga, N