The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention.
The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery: A meta-analysis for time of intervention.
复制标题
DOI：
10.1016/j.aopr.2022.100063
复制
发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
白内障术后3%地夸磷索治疗的干预时间的影响尚未得到很好的确定。进行了一项荟萃分析，以评价接受3% DQS不同治疗持续时间的白内障手术后患者的眼表状况改善。研究基于5个数据库进行：PubMed、科克伦图书馆、Web of Science、Embase和中国国家知识基础设施。收集泪液分泌试验、泪膜破裂时间（TBUT）、角膜染色评分和OSDI评分的变化数据进行荟萃分析。共纳入了来自9项独立临床研究的621只患眼。6项研究在应用3%DQS后进行Schirmer试验。荟萃分析显示，3% DQS组与对照组在短期应用（≤ 1个月）时差异无统计学意义（WMD = 0.14，P = 0.27，95%CI：-0.11至0.39），但在长期应用（≥ 3个月）时差异有统计学意义（WMD = 0.76，P = 0.03，95%CI：0.08至1.45）。对于角膜荧光染色评分，6项研究的数据表明，短期应用（WMD =-0.40，P <0.00001，95% CI：-0.72至-0.08）的改善具有统计学意义，而长期应用（WMD =-0.21，P = 0.26，95% CI：-0.57至0.15）的改善无统计学意义。对于TBUT，来自9项研究的数据表明，短期和长期应用均显示出显著改善（WMD = 1.70，P <0.00001，95% CI：1.38至2.03; WMD = 1.52，P <0.00001，95% CI：1.09至1.95）。在5项OSDI评分研究的数据中观察到类似结果，短期和长期应用均显示统计学显著改善（WMD =-5.41，P <0.00001，95%CI：-7.02至-3.81; WMD =-6.10，P <0.00001，95%CI：-8.52至-3.67）。白内障术后应用3%DQS对改善眼表状况有积极作用。短期应用导致角膜染色评分降低，TBUT延长，OSDI评分改善。长期应用可改善Schirmer试验结果、TBUT和主观症状。更新的文章表明，3%地夸磷索在白内障手术后的短期内效果较差，应用三个月以上可以改善患者的眼表状况。
The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established. A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment durations. Studies were performed based on 5 databases: PubMed, Cochrane Library, Web of Science, Embase, and China National Knowledge Infrastructure. Data on changes in Schirmer’s test, tear breakup time (TBUT), corneal staining score, and OSDI score were collected for meta-analysis. A total of 621 affected eyes from 9 independent clinical studies were included. 6 studies conducted Schirmer's test after the application of 3% DQS. Meta-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application (less than or equal to 1 month) (WMD = 0.14, P = 0.27, 95% CI:-0.11 to 0.39), but was statistically different for long-term application (longer than or equal to 3 months) (WMD = 0.76, P = 0.03, 95% CI:0.08 to 1.45). For the corneal fluorescence staining score, the data from 6 studies indicated that the improvement was statistically significant for short-term application (WMD = -0.40, P <0.00001, 95% CI:-0.72 to -0.08) and but not long-term application (WMD = -0.21, P = 0.26, 95% CI:-0.57 to 0.15). For TBUT, the data from 9 studies indicated that both short-term and long-term application showed significant improvement (WMD = 1.70, P <0.00001, 95% CI:1.38 to 2.03; WMD = 1.52, P <0.00001, 95% CI:1.09 to 1.95). Similar results were observed in data from 5 studies with OSDI scores, where both short-term and long-term application showed statistically significant improvements (WMD = -5.41, P <0.00001, 95% CI: -7.02 to -3.81; WMD = -6.10, P <0.00001, 95% CI:-8.52 to -3.67). The application of 3% DQS in post-operative cataract patients has a positive effect on improving the ocular surface conditions. Short-term application resulted in lower corneal staining scores, prolonged TBUT, and improved OSDI scores. Long-term application improved Schirmer's test results, TBUT, and subjective symptoms. The updated article suggests that 3% Diquafosol is less effective in the short term after cataract surgery, and that application over three months can improve the patient's ocular surface condition.
登录
查看更多内容
影响因子：
--
作者：
Cho YK;Kim MS
通讯作者：
Kim MS
影响因子：
4.2
作者：
Park, Dae Hyun;Chung, Jin Kwon;Lee, Sung Jin
通讯作者：
Lee, Sung Jin
影响因子：
2
作者：
Baek, Jiwon;Doh, Sang Hee;Chung, Sung Kun
通讯作者：
Chung, Sung Kun
影响因子：
2.8
作者：
Li, Xue-Min;Hu, Lizhong;Wang, Wei
通讯作者：
Wang, Wei
影响因子：
1.6
作者：
Zhao X;Xia S;Chen Y
通讯作者：
Chen Y