Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice.
Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice.
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吸入的姜酮可以通过不同于口服给药的途径掺入器官中，并且可以影响小鼠的体重增加。
DOI：
10.1038/s41598-022-15168-9
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发表时间：
2022-06-30
影响因子：
4.6
通讯作者：
Zaima, Nobuhiro
中科院分区：
文献类型：
--
作者：
Takemoto, Yuki;Kishi, Chihiro;Ehira, Hinano;Matsui, Nobutaka;Yamaguchi, Taichi;Yoshioka, Yuri;Matsumura, Shinichi;Moriyama, Tatsuya;Zaima, Nobuhiro
姜黄酮（α-姜黄酮、β-姜黄酮和ar-姜黄酮）是姜黄（姜黄科多年生草本植物）中的主要挥发性化合物。我们以前报道过吸入挥发性姜黄酮可以在血液和器官中转移。然而，口服和吸入两种途径的区别以及吸入的姜黄酮对生物活性的影响尚不清楚。在本研究中，我们比较了口服和吸入后的姜黄酮的分布规律。吸入组肺、嗅球、脑、心、肾和附睾脂肪的相对水平（各器官/血清中的姜黄酮浓度）倾向于或显著高于口服组。吸入组棕色脂肪组织相对水平低于口服组。长期（50天）吸入挥发性姜黄酮可抑制高脂肪饮食小鼠的体重增加和附睾脂肪中脂肪细胞的肥大。这些结果表明，吸入的姜黄酮与口服的姜黄酮可以通过不同的途径进入小鼠的器官，并在一定条件下影响器官的生物学功能。
Turmerones (α-turmerone, β-turmerone, and ar-turmerone) are the major volatile compounds in turmeric (Curcuma longa), a perennial herb of the ginger family. We previously reported that inhaled volatile turmerones could be transferred in the blood and organs. However, the difference between the two pathways, oral administration and inhalation, and the effect of inhaled turmerones on biological activities remain unknown. In this study, we compared the distribution patterns of turmerones after oral administration and inhalation. The relative levels (concentrations of turmerones in each organ/serum) in the lung, olfactory bulb, brain, heart, kidney, and epididymal fat in the inhalation group tended to be, or are significantly, higher than in the oral administration group. The relative levels of brown adipose tissue in the inhalation group were lower than in the oral administration group. Long-term (50 days) inhalation to volatile turmerones suppressed weight gain and hypertrophy of adipocytes in the epididymal fat of mice fed a high-fat diet. These results suggest that inhaled turmerones can be incorporated into the organs of mice via different pathway from as to those from oral administration and can affect the biological function of the organs under certain conditions.
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