Functional and anatomical relationships between the medial precentral cortex, dorsal striatum, and head direction cell circuitry. II. Neuroanatomical studies.
Functional and anatomical relationships between the medial precentral cortex, dorsal striatum, and head direction cell circuitry. II. Neuroanatomical studies.
复制标题
内侧中央前皮质、背侧纹状体和头部方向细胞电路之间的功能和解剖关系。
DOI：
10.1152/jn.00144.2018
复制
发表时间：
2019
影响因子：
2.5
通讯作者：
Taube,JeffreyS
中科院分区：
文献类型：
--
作者：
Mehlman,MaxL;Winter,ShawnS;Taube,JeffreyS
动物在其环境中的定向方向是由头部方向（HD）细胞的活动编码的。在啮齿类动物中，这些神经元主要存在于边缘系统中形成边缘HD回路的相互连接的结构中。在本期的相关报道中，我们描述了位于内侧中央前皮层（PrCM）和背纹状体（DS）回路外的两个HD细胞群。这些边缘外区域接收来自边缘系统的HD信号，但不向边缘HD细胞提供关键的输入或反馈（Mehlman ML, Winter SS, Valerio S, Taube JS）。[J] .中国生物医学工程学报，2016,31(2):357 - 357。在本报告中，我们补充了之前的损伤和记录实验，在大鼠中进行了一系列神经解剖学追踪研究，旨在检查PrCM、DS、边缘HD回路和相关空间处理回路之间的连接模式。逆行追踪显示，DS接收来自许多已知包含HD细胞和/或其他空间调谐细胞类型的结构的直接输入。重要的是，这些投射优先瞄准并聚集在DS的最内侧部分，这与我们之前记录HD细胞的区域相同。PrCM接收来自这些空间处理结构子集的直接输入。顺行追踪发现了PrCM和DS将自我运动信息传递给边缘HD电路的间接途径。这些追踪研究揭示了在我们的病变和记录实验中观察到的功能关系的解剖学基础。总的来说，这些发现扩大了我们对空间处理电路在功能和解剖学上如何从边缘系统延伸到PrCM和DS的理解。头部定向（HD）细胞主要位于边缘系统内，但在内侧中央前皮层（PrCM）和背纹状体（DS）中发现了少量边缘外HD细胞。本文报道的神经解剖学追踪实验探索了能够将HD信号传递到这些边缘外区域的途径。我们发现，许多空间处理结构产生的投影在含有HD细胞的PrCM和DS部分收敛。
An animal’s directional heading within its environment is encoded by the activity of head direction (HD) cells. In rodents, these neurons are found primarily within the limbic system in the interconnected structures that form the limbic HD circuit. In our accompanying report in this issue, we describe two HD cell populations located outside of this circuit in the medial precentral cortex (PrCM) and dorsal striatum (DS). These extralimbic areas receive their HD signals from the limbic system but do not provide critical input or feedback to limbic HD cells (Mehlman ML, Winter SS, Valerio S, Taube JS.J Neurophysiol121: 350–370, 2019.). In this report, we complement our previous lesion and recording experiments with a series of neuroanatomical tracing studies in rats designed to examine patterns of connectivity between the PrCM, DS, limbic HD circuit, and related spatial processing circuitry. Retrograde tracing revealed that the DS receives direct input from numerous structures known to contain HD cells and/or other spatially tuned cell types. Importantly, these projections preferentially target and converge within the most medial portion of the DS, the same area in which we previously recorded HD cells. The PrCM receives direct input from a subset of these spatial processing structures. Anterograde tracing identified indirect pathways that could permit the PrCM and DS to convey self-motion information to the limbic HD circuit. These tracing studies reveal the anatomical basis for the functional relationships observed in our lesion and recording experiments. Collectively, these findings expand our understanding of how spatial processing circuitry functionally and anatomically extends beyond the limbic system into the PrCM and DS.NEW & NOTEWORTHYHead direction (HD) cells are located primarily within the limbic system, but small populations of extralimbic HD cells are found in the medial precentral cortex (PrCM) and dorsal striatum (DS). The neuroanatomical tracing experiments reported here explored the pathways capable of transmitting the HD signal to these extralimbic areas. We found that projections arising from numerous spatial processing structures converge within portions of the PrCM and DS that contain HD cells.
登录
查看更多内容
内嗅传出神经到达尾壳核
影响因子：
2.5
作者：
K. E. Sørensen;M. Witter
通讯作者：
M. Witter
影响因子：
2.7
作者：
KOLB, B;WALKEY, J
通讯作者：
WALKEY, J
影响因子：
7.7
作者：
Jankowski MM;Islam MN;Wright NF;Vann SD;Erichsen JT;Aggleton JP;O'Mara SM
通讯作者：
O'Mara SM
大鼠后皮质中的头部方向细胞
影响因子：
2
作者：
Longtang L. Chen;Lie‐Huey Lin;C. Barnes;Brace L. McNaughton
通讯作者：
Brace L. McNaughton
影响因子：
3.8
作者：
REEP, RL;CORWIN, JV;WATSON, RT
通讯作者：
WATSON, RT