Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk.
Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk.
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细菌群体感应系统及其在肠道细菌-宿主串扰中的作用
DOI：
10.3389/fmicb.2021.611413
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发表时间：
2021
影响因子：
5.2
通讯作者：
Luo Y
中科院分区：
文献类型：
--
作者：
Wu L;Luo Y
群体感应(QS)系统是一个发展迅速的领域，我们正在逐步扩大我们对细菌之间如何相互沟通和调节它们在细菌社会活动中的活动的理解。除了集体改变细菌的行为外，QS相关的自动诱导剂也可能嵌入宿主和寄生微生物之间的串扰中。本文就QS在肠道微生物组领域的研究现状及其在生理条件下维持体内平衡的潜在作用作一综述。此外，我们概述了典型的自身诱导物及其相关的QS信号-反应系统，通过这些系统，几种病原体在病理条件下与宿主相互作用，目的是更好地了解肠道细菌的社会性，并促进新的抗菌治疗策略。
Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality. In addition to collectively modifying bacterial behavior, QS-related autoinducers may also be embedded in the crosstalk between host and parasitic microbes. In this review, we summarize current studies on QS in the intestinal microbiome field and its potential role in maintaining homeostasis under physiological conditions. Additionally, we outline the canonical autoinducers and their related QS signal-response systems by which several pathogens interact with the host under pathological conditions, with the goal of better understanding intestinal bacterial sociality and facilitating novel antimicrobial therapeutic strategies.
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