Inhibition of RNA degradation integrates the metabolic signals induced by osmotic stress into the Arabidopsis circadian system.
Inhibition of RNA degradation integrates the metabolic signals induced by osmotic stress into the Arabidopsis circadian system.
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RNA 降解的抑制将渗透压诱导的代谢信号整合到拟南芥昼夜节律系统中。
DOI：
10.1093/jxb/erad274
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发表时间：
2023-09-29
影响因子：
6.9
通讯作者：
Jones, Matthew Alan
中科院分区：
文献类型：
--
作者：
Prasetyaningrum, Putri;Litthauer, Suzanne;Vegliani, Franco;Battle, Martin William;Wood, Matthew William;Liu, Xinmeng;Dickson, Cathryn;Jones, Matthew Alan
生物钟系统作为一个内源性的时间参考，协调许多代谢和生理过程中的植物。以前的研究表明，渗透压的应用延迟昼夜节律通过3-磷酸腺苷5-磷酸（PAP），逆行信号代谢产物，产生的细胞器内的氧化还原应激反应。PAP积累导致负责RNA降解的核糖核酸外切酶（XRN）的抑制。有趣的是，我们现在能够证明，转录后处理是至关重要的昼夜节律响应渗透胁迫。我们的数据表明，渗透胁迫增加了特定的昼夜节律RNA的稳定性，这表明RNA代谢在干旱期间的生物钟协调中起着至关重要的作用。XRN 4的失活足以延长昼夜节律作为这种反应的一部分，PRR 7和LWD 1被鉴定为转录后调节以延迟昼夜节律进展的转录物。PRR 7和LWD 1的转录后调节通过核糖核酸外切酶XRN 4使昼夜节律系统响应渗透胁迫。
The circadian clock system acts as an endogenous timing reference that coordinates many metabolic and physiological processes in plants. Previous studies have shown that the application of osmotic stress delays circadian rhythms via 3ʹ-phospho-adenosine 5ʹ-phosphate (PAP), a retrograde signalling metabolite that is produced in response to redox stress within organelles. PAP accumulation leads to the inhibition of exoribonucleases (XRNs), which are responsible for RNA degradation. Interestingly, we are now able to demonstrate that post-transcriptional processing is crucial for the circadian response to osmotic stress. Our data show that osmotic stress increases the stability of specific circadian RNAs, suggesting that RNA metabolism plays a vital role in circadian clock coordination during drought. Inactivation of XRN4 is sufficient to extend circadian rhythms as part of this response, with PRR7 and LWD1 identified as transcripts that are post-transcriptionally regulated to delay circadian progression. Post-transcriptional regulation of PRR7and LWD1transcripts by the exoribonuclease XRN4 enables the circadian system to respond to osmotic stress.
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